Gene expression patterns in human liver cancers
Gene expression patterns in human liver cancers
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DOI：
10.1091/mbc.02-02-0023
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发表时间：
2002-06-01
影响因子：
3.3
通讯作者：
Brown, PO
中科院分区：
文献类型：
--
作者：
Chen, X;Cheung, ST;Brown, PO
肝细胞癌（HCC）是世界范围内的主要死亡原因。使用cDNA微阵列来表征HCC中的基因表达模式，我们发现HCC中的表达模式与非肿瘤肝组织中的表达模式之间存在一致的差异。HCC中的表达模式也容易与转移到肝的肿瘤相关的表达模式区分开。每个肿瘤固有的全局基因表达模式是足够独特的，来自同一患者的多个肿瘤结节通常可以单独基于其基因表达模式识别并与大样本集中的所有其他肿瘤结节区分开。独特的基因表达模式是肿瘤的特征，而不是患者的特征;在同一患者的克隆独立肿瘤结节中观察到的表达程序并不比来自不同患者的肿瘤中的表达程序更相似。此外，克隆相关的肿瘤块，表现出不同的表达谱也区分基因型差异。基因表达模式的一些特征与肿瘤的特定表型和基因型特征相关，包括生长速率、血管浸润和p53过表达。
Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Using cDNA microarrays to characterize patterns of gene expression in HCC, we found consistent differences between the expression patterns in HCC compared with those seen in nontumor liver tissues. The expression patterns in HCC were also readily distinguished from those associated with tumors metastatic to liver. The global gene expression patterns intrinsic to each tumor were sufficiently distinctive that multiple tumor nodules from the same patient could usually be recognized and distinguished from all the others in the large sample set on the basis of their gene expression patterns alone. The distinctive gene expression patterns are characteristic of the tumors and not the patient; the expression programs seen in clonally independent tumor nodules in the same patient were no more similar than those in tumors from different patients. Moreover, clonally related tumor masses that showed distinct expression profiles were also distinguished by genotypic differences. Some features of the gene expression patterns were associated with specific phenotypic and genotypic characteristics of the tumors, including growth rate, vascular invasion, and p53 overexpression.