Increased inflammatory responses of persons of blood group O to Helicobacter pylori
Increased inflammatory responses of persons of blood group O to Helicobacter pylori
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DOI：
10.1086/315375
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发表时间：
2000-04-01
影响因子：
6.4
通讯作者：
Weir, DM
中科院分区：
文献类型：
--
作者：
Alkout, AM;Blackwell, CC;Weir, DM
O型血的人患消化性溃疡的风险增加。幽门螺杆菌与O血型人的上皮细胞的结合增强已被证实。在体外与H.幽门。分离物DU（来自患有十二指肠溃疡的患者）、GC（来自患有胃癌的患者）、NE（来自具有正常内窥镜检查结果的患者）和NCTC 11637以显著更高的数量与O型白细胞结合。细菌结合与IL-6和TNF-α的释放相关，但与IL-10的释放无关。O组细胞响应于DU、NE和NCTC 11637而释放显著更多的IL-6，并且细胞响应于DU和NCTC 11637而释放更多的TNF-α。上皮细胞定植密度增加，对H. O型血者的pylori感染可能增加消化性溃疡的易感性。
Persons of blood group O are at increased risk of peptic ulcers. Enhanced binding of Helicobacter pylori to epithelial cells of persons of blood group O has been demonstrated. Release of interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-alpha by human leukocytes from 40 donors (10 from each ABO blood group) was measured after incubation in vitro with outer membrane protein preparations of H. pylori. Isolates DU (from a patient with a duodenal ulcer), GC (from a patient with gastric cancer), NE (from a patient with normal endoscopic findings), and NCTC 11637 bound in significantly higher numbers to group O leukocytes. Bacterial binding correlated with release of IL-6 and TNF-alpha but not of IL-10. Group O cells released significantly more IL-6 in response to DU, NE, and NCTC 11637, and the cells released more TNF-alpha in response to DU and NCTC 11637. Increased density of colonization of epithelial cells and higher inflammatory responses to H. pylori of persons of blood group O might contribute to increased susceptibility to peptic ulceration.