The choreography of neuroinflammation in Huntington's disease.
The choreography of neuroinflammation in Huntington's disease.
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DOI：
10.1016/j.it.2015.04.007
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发表时间：
2015-06
影响因子：
16.8
通讯作者：
Glass CK
中科院分区：
文献类型：
--
作者：
Crotti A;Glass CK
目前，“神经炎症”的概念包括与神经退行性疾病相关的炎症，其中血液来源的免疫细胞很少或没有渗透到大脑中。脑驻留和外周免疫细胞在这些炎症环境中的作用知之甚少，并且尚不清楚神经炎症是否由对神经元功能障碍/变性的免疫反应引起，和/或代表功能障碍免疫细胞的细胞自主表型。在这里，我们回顾了最近的研究检查这些问题的背景下，亨廷顿病（HD），其中突变亨廷顿蛋白（HTT）的神经元和胶质细胞的表达。深入了解HD中神经炎症的细胞和分子机制可能有助于更好地理解更复杂的神经退行性疾病中的炎症，以及神经炎症组分对神经退行性疾病发病机制的贡献。
Currently, the concept of ‘neuroinflammation’ includes inflammation associated with neurodegenerative diseases, in which there is little or no infiltration of blood-derived immune cells into the brain. The roles of brain-resident and peripheral immune cells in these inflammatory settings are poorly understood, and it is unclear whether neuroinflammation results from immune reaction to neuronal dysfunction/degeneration, and/or represents cell-autonomous phenotypes of dysfunctional immune cells. Here, we review recent studies examining these questions in the context of Huntington’s disease (HD), where mutant Huntingtin (HTT) is expressed in both neurons and glia. Insights into the cellular and molecular mechanisms underlying neuroinflammation in HD may provide a better understanding of inflammation in more complex neurodegenerative disorders, and of the contribution of the neuroinflammatory component to neurodegenerative disease pathogenesis.