Negative Urgency Mediates the Relationship between Amygdala and Orbitofrontal Cortex Activation to Negative Emotional Stimuli and General Risk-Taking
Negative Urgency Mediates the Relationship between Amygdala and Orbitofrontal Cortex Activation to Negative Emotional Stimuli and General Risk-Taking
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DOI：
10.1093/cercor/bhu123
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发表时间：
2015-11-01
期刊：
影响因子：
3.7
通讯作者：
Kareken, David A.
中科院分区：
文献类型：
--
作者：
Cyders, Melissa A.;Dzemidzic, Mario;Kareken, David A.
在情绪胁迫下的冲动行为倾向（消极和积极的紧迫性）预示着广泛的适应不良的冒险行为和行为障碍。然而，目前尚不清楚紧迫感与由情绪刺激引起的边缘系统活动之间的关系。本研究使用功能性磁共振成像技术来研究大脑对视觉情绪刺激的反应与急迫性特征之间的关系。27名社交饮酒者（平均年龄25.2岁，14名男性）在6次fMRI扫描中看到了阴性（Neg）、中性（Neu）和阳性（Pos）图像。大脑激活是从先前在情绪刺激研究中发现的先验边缘区域提取的。在[Neg>Neu]对比中，右侧后眼窝前额皮质（OFC）和左侧杏仁核被激活，而在[Pos>Neu]对比中，左侧后眼窝前额皮质（OFC）被激活。阴性急迫感与右侧OFC （r = 0.43, P = 0.03）和左侧杏仁核（r = 0.39, P = 0.04） [Neg>Neu]激活有关。负紧迫感还介导了[Neg>Neu]激活与一般冒险行为之间的关系（右侧OFC和左侧杏仁核的回归权重分别为3.42和2.75）。情绪线索诱发的右外侧OFC和左杏仁核激活可能与负紧急性下基于情绪的冒险行为有关。
The tendency toward impulsive behavior under emotional duress (negative and positive urgency) predicts a wide range of maladaptive risk-taking and behavioral disorders. However, it remains unclear how urgency relates to limbic system activity as induced from emotional provocation. This study used functional magnetic resonance imaging to examine the relationship between brain responses to visual emotional stimuli and urgency traits. Twenty-seven social drinkers (mean age = 25.2, 14 males) viewed negative (Neg), neutral (Neu), and positive (Pos) images during 6 fMRI scans. Brain activation was extracted from a priori limbic regions previously identified in studies of emotional provocation. The right posterior orbitofrontal cortex (OFC) and left amygdala were activated in the [Neg>Neu] contrast, whereas the left posterior OFC was activated in the [Pos>Neu] contrast. Negative urgency was related to the right lateral OFC (r = 0.43, P = 0.03) and the left amygdala (r = 0.39, P = 0.04) [Neg>Neu] activation. Negative urgency also mediated the relationship between [Neg>Neu] activation and general risk-taking (regression weights = 3.42 for right OFC and 2.75 for the left amygdala). Emotional cue-induced activation in right lateral OFC and left amygdala might relate to emotion-based risk-taking through negative urgency.