Electrochemical Bubble-Based Bidirectional Microfluidic Transport
Electrochemical Bubble-Based Bidirectional Microfluidic Transport
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DOI：
10.1021/acssensors.5b00059
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发表时间：
2016-02-01
期刊：
影响因子：
8.9
通讯作者：
Suzuki, Hiroaki
中科院分区：
文献类型：
--
作者：
Obata, Hirotaka;Kuji, Tomoaki;Suzuki, Hiroaki
以应用于生化分析为目的，通过可逆电化学产生和收缩氢气泡来实现有效的双向微流体传输。将具有铂黑工作电极、Ag/AgCl参比电极和铂辅助电极的三电极系统并入含有必要的流动通道和隔室的聚（二甲基硅氧烷）结构中。考察了电极结构和流道结构对系统运行的影响。气泡的产生和收缩是通过向工作电极施加适当的电位来实现的，这最小化了由溶解氧的氧化作用引起的自发收缩的影响。器件性能取决于工作电极的结构，这意味着需要进一步优化。该装置被示出为通过微创针抽取溶液，并在微流体系统中处理液体塞。
With the aim of application to biochemical analyses, efficient bidirectional microfluidic transport was achieved through the reversible electrochemical production and shrinkage of hydrogen bubbles. A three electrode system with a platinum black working electrode, a Ag/AgCl reference electrode, and a platinum auxiliary electrode was incorporated into a poly(dimethylsiloxane) structure containing the necessary flow channels and compartments. The influence of the electrode and flow channel structures on the operation of the system was investigated. The production and shrinkage of bubbles was achieved by applying appropriate potentials to the working electrode, which minimized the influence of spontaneous shrinkage resulting from the oxidizing effect of dissolved oxygen. Device performance depended on the structure of the working electrode, meaning that further optimization will be necessary. The device was shown to withdraw solution through a minimally invasive needle and to process liquid plugs in a microfluidic system.