Cytotoxicity of mesoporous silica nanomaterials
Cytotoxicity of mesoporous silica nanomaterials
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DOI：
10.1016/j.jinorgbio.2007.12.028
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发表时间：
2008-07-01
影响因子：
3.9
通讯作者：
Asefa, Tewodros
中科院分区：
文献类型：
--
作者：
Di Pasqua, Anthony J.;Sharma, Krishna K.;Asefa, Tewodros
我们测量了介孔二氧化硅纳米材料MCM-41及其两个功能化类似物AP-T和MP-T对人神经母细胞瘤(SK-N-SH)细胞的毒性。由于所研究的颗粒不溶于水介质，用于报告这些材料的细胞毒性的指标是一个新的数量Q(50)，这是抑制正常细胞生长50%所需的颗粒数量。要确定应用于电池的每克材料的颗粒数量，需要计算和实验确定这些纳米材料的表面积。这项研究表明，Q50的增加顺序为MCM-41<；MP-T<；AP-T接近于SiO_2，表明从每个颗粒的角度来看，MCM-41是所研究的细胞毒性最强的材料。对于本研究中的三种介孔二氧化硅材料，细胞毒性似乎与颗粒的吸附表面积有关，尽管不能排除官能团的性质。在所研究的颗粒中，二氧化硅纳米球的比表面积最小，但由于它们的Q(50)值与AP-T相似，因此形状也可能对这些材料的细胞毒性起到重要作用。(C)2008 Elsevier Inc.保留所有权利。
We here measure the toxicity of MCM-41, a mesoporous silica nanomaterial, two of its functionalized analogs, AP-T, which has grafted aminopropyl groups and MP-T, which has grafted mercaptopropyl groups, and spherical silica nanoparticles (SiO2), toward human neuroblastorna (SK-N-SH) cells. Since the particles studied are not soluble in aqueous media, the metric used to report the cytotoxicity of these materials is a new quantity, Q(50), which is the number of particles required to inhibit normal cell growth by 50%. Determining the number of particles per gram of material applied to the cells required both the calculated and experimentally determined surface areas of these nanomaterials. This study shows that Q50 increases in the order, MCM-41 < MP-T < AP-T approximate to SiO2, showing that on a per particle basis, MCM-41 is the-most cytotoxic material studied. For the three mesoporous silica materials in this study, cytotoxicity appears related to the adsorptive surface area of the particle, although the nature of the functional group cannot be ruled out. Silica nanospheres have the lowest surface area of the particles studied but since they exhibit a Q(50) value similar to that of AP-T, shape may also be important in the cytotoxicity of these materials. (c) 2008 Elsevier Inc. All rights reserved.