The Sca-1 cell surface marker enriches for a prostateregenerating cell subpopulation that can initiate prostate tumorigenesis
The Sca-1 cell surface marker enriches for a prostateregenerating cell subpopulation that can initiate prostate tumorigenesis
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DOI：
10.1073/pnas.0502320102
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发表时间：
2005-05-10
影响因子：
11.1
通讯作者：
Witte, ON
中科院分区：
文献类型：
--
作者：
Xin, L;Lawson, DA;Witte, ON
Sca-1（干细胞抗原-1）富集能够在解离细胞前列腺再生系统中再生包含基底和腔细胞谱系的管状结构的鼠前列腺细胞。Sca-1（+）组分富集细胞周期G（0）期的细胞，Sca-1（+）细胞聚集在前列腺小管的近端区域，其中复制静止细胞已被定位。去势诱导的雄激素非依赖性细胞的富集导致Sca-1（+）细胞的伴随富集。前列腺再生细胞中PTEN/AKT信号的遗传扰动导致肿瘤发生的开始，并且癌症进展与Sca-1（+）细胞的急剧增加相关。富含Sca-1的前列腺再生细胞具有多种干/祖细胞特性，可作为癌症起始的靶点。
Sca-1 (stem cell antigen-1) enriches for murine prostate cells capable of regenerating tubular structures containing basal and luminal cell lineages in a dissociated cell prostate regeneration system. Sca-1(+) fractions are enriched for cells at the G(0) stage of the cell cycle, and Sca-1(+) cells cluster in the proximal region of prostatic tubules where replication-quiescent cells have been localized. Castration-induced enrichment for androgen-independent cells results in a concomitant enrichment for Sca-1(+) cells. Genetic perturbations of PTEN/AKT signaling in prostate-regenerating cells leads to the initiation of tumorigenesis, and cancer progression is associated with a dramatic increase in Sca-1(+) cells. Sca-1-enriched prostate-regenerating cells possess multiple stem/progenitor cell properties and can serve as targets for cancer initiation.