Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling.
Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling.
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DOI：
10.1124/jpet.301.1.1
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发表时间：
2002-04
期刊：
影响因子：
--
通讯作者：
U. Sonnewald;H. Qu;M. Aschner
中科院分区：
文献类型：
--
作者：
U. Sonnewald;H. Qu;M. Aschner
从谷氨酸神经毒性的角度研究了星形胶质细胞和神经元之间的相互作用。该综述详细介绍了1.星形胶质细胞和神经元上谷氨酸转运体的分布，引起了对这两种细胞在清除细胞外谷氨酸和防止兴奋性毒性损伤中相互依赖的重新表述；2.谷氨酸转运体功能异常在神经病理疾病的病因中的潜在参与；3.星形胶质细胞-神经元相互作用在脑能学的广泛不同方面的作用；4.在戊巴比妥和硫喷妥钠麻醉治疗的背景下，星形胶质细胞在谷氨酸循环过程中的作用。
The interaction between astrocytes and neurons is examined from the standpoint of glutamate neurotoxicity. The review details 1. the distribution of glutamate transporters on astrocytes and neurons, provoking a reformulation of the interdependence between these two cell types in removing extracellular glutamate and preventing excitotoxic injury; 2. the potential involvement of aberrant glutamate transporter function in the etiology of neuropathological conditions; 3. the role of astrocyte-neuron interaction in widely divergent aspects of brain energetics; 4. the role of astrocytes in the process of glutamate recycling within the context of anesthetic treatment with pentobarbital and thiopental.