Increased carotid wall thickening after radiotherapy on the neck
Increased carotid wall thickening after radiotherapy on the neck
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DOI：
10.1016/j.ejca.2005.01.020
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发表时间：
2005-05-01
影响因子：
8.4
通讯作者：
Boogerd, W
中科院分区：
文献类型：
--
作者：
Dorresteijn, LDA;Kappelle, AC;Boogerd, W
通过颈部局部放疗（RT）治疗头颈部肿瘤的患者中风的风险增加。这可能是由于 RT 场内动脉粥样硬化变化加速所致；然而，局部放疗对颈动脉的真正影响仍然存在争议。本研究的目的是通过 B 型超声检查评估 42 名单侧接受照射的腮腺肿瘤患者颈动脉壁厚度（内膜中层厚度）的差异。与未照射颈动脉相比，照射颈动脉的内膜中层厚度 (IMT) 平均差异为 0.30 毫米 (P = 0.031)。与较长的 RT 后间隔建立了显着相关性 (P = 0.008)。颈部放疗与颈动脉 IMT 增厚有关。建议筛查和治疗导致 IMT 进一步增厚和卒中发展的其他脑血管危险因素，特别是对于预后良好的放疗患者。 (c) 2005 Elsevier Ltd. 保留所有权利。
Patients treated for head and neck tumours with local radiotherapy (RT) on the neck harbour an increased risk of stroke. This may be due to accelerated atherosclerotic changes within the RT-field; however, the real impact of local RT on the carotid artery remains debatable. The aim of the present study was to assess the difference in carotid wall thickness (intima-media thickness) in 42 unilaterally irradiated parotid tumour patients by performing B-mode ultrasonography. A mean difference in intima-media thickness (IMT) of the irradiated compared with the non-irradiated carotid artery of 0.30 mm (P = 0.031) was found. A significant correlation was established with a longer post-RT interval (P = 0.008). RT on the neck is associated with increased thickening of carotid IMT. Screening and treatment of additional cerebrovascular risk factors which contribute to further IMT thickening and stroke development is recommended, especially in radiotherapy patients with a favourable prognosis. (c) 2005 Elsevier Ltd. All rights reserved.