Weak expression of blood type B antigen in kidney tissue and successful B-incompatible kidney transplantation without special treatments.
Weak expression of blood type B antigen in kidney tissue and successful B-incompatible kidney transplantation without special treatments.
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肾组织中B型血抗原弱表达，无需特殊治疗即可成功进行B型不相容肾移植。
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
R. Omoto
中科院分区：
文献类型：
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作者：
I. Koyama;Y. Taguchi;S. Sugahara;N. Akimoto;R. Omoto
在ABO血型不合肾移植中，受者的自然抗体滴度一直受到关注。在这项研究中，我们观察了肾组织中血型抗原的分布。收集了37例肾炎或移植肾患者的活检标本。A型15例，B型14例，AB型8例。采用免疫组织化学染色法，用抗A或抗B抗体对肾组织进行染色。以每个切片上的染色点为面积，用图像分析仪进行测量。与A抗原相比，B抗原在肾小球和肾小球中的表达非常弱。在AB型中，B抗原的表达低于A抗原。基于这些结果，我们进行了B血型不合的肾移植。术前未清除天然抗体和脾切除，未见排斥反应。这些结果可能表明，B型不相容的肾移植可能可以在术前不耗尽天然抗体的情况下进行。
Much attention has been paid to only natural antibody titer of the recipients in ABO-incompatible kidney transplantation. In this study, we looked at the distribution of blood type antigens in the kidney tissue. Thirty-seven biopsy specimens from patients with nephritis or transplanted kidneys were recruited. Fifteen were type A, 14 were type B, and 8 were type AB. Kidney tissues were stained with anti-A or anti-B antibody using immunohistological staining. The stained dots in each section were regarded as the area and were measured by image analyzer. B antigen was expressed very weakly both in the glomeruli and in interstitium as compared with A antigen. In type AB, B antigen was less expressed than A antigen. Based on these results, we performed B-incompatible kidney transplantation. No rejection was seen without preoperative depletion of natural antibody and splenectomy. These results may suggest that type B-incompatible kidney transplantation might possibly be performed without preoperative depletion of natural antibodies.
ABO 不相容肾移植：初始免疫病理学评估。
影响因子：
0.9
作者：
Chopek,MW;Simmons,RL;Platt,JL
通讯作者：
Platt,JL