Patients with COVID-19: in the dark-NETs of neutrophils.
Patients with COVID-19: in the dark-NETs of neutrophils.
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DOI：
10.1038/s41418-021-00805-z
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发表时间：
2021-11
影响因子：
12.4
通讯作者：
Herrmann M
中科院分区：
文献类型：
--
作者：
Ackermann M;Anders HJ;Bilyy R;Bowlin GL;Daniel C;De Lorenzo R;Egeblad M;Henneck T;Hidalgo A;Hoffmann M;Hohberger B;Kanthi Y;Kaplan MJ;Knight JS;Knopf J;Kolaczkowska E;Kubes P;Leppkes M;Mahajan A;Manfredi AA;Maueröder C;Maugeri N;Mitroulis I;Muñoz LE;Narasaraju T;Naschberger E;Neeli I;Ng LG;Radic MZ;Ritis K;Rovere-Querini P;Schapher M;Schauer C;Simon HU;Singh J;Skendros P;Stark K;Stürzl M;van der Vlag J;Vandenabeele P;Vitkov L;von Köckritz-Blickwede M;Yanginlar C;Yousefi S;Zarbock A;Schett G;Herrmann M
SARS-CoV-2感染对肺部和其他多个器官构成重大威胁，偶尔会导致死亡。在开发出有效的疫苗来遏制大流行之前，最重要的是确定机制并开发保护性疗法，以预防COVID-19患者的器官功能障碍。发展严重表现的个体具有先天性和适应性免疫反应失调的迹象。新出现的证据表明，中性粒细胞和中性粒细胞胞外陷阱（NET）形成和降解之间的失衡在炎症、凝血病、器官损伤和免疫血栓形成的病理生理学中起着核心作用，这些疾病是COVID-19严重病例的特征。在这里，我们讨论了支持NET在COVID-19表现中的作用的证据，并提出了NET促进组织损伤和免疫血栓形成的假定机制。我们提出了治疗策略，这些治疗策略在治疗免疫炎症性疾病方面取得了成功，并且靶向失调的NET形成或降解，作为可能使严重COVID-19患者受益的潜在方法。
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs, occasionally causing death. Until effective vaccines are developed to curb the pandemic, it is paramount to define the mechanisms and develop protective therapies to prevent organ dysfunction in patients with COVID-19. Individuals that develop severe manifestations have signs of dysregulated innate and adaptive immune responses. Emerging evidence implicates neutrophils and the disbalance between neutrophil extracellular trap (NET) formation and degradation plays a central role in the pathophysiology of inflammation, coagulopathy, organ damage, and immunothrombosis that characterize severe cases of COVID-19. Here, we discuss the evidence supporting a role for NETs in COVID-19 manifestations and present putative mechanisms, by which NETs promote tissue injury and immunothrombosis. We present therapeutic strategies, which have been successful in the treatment of immunο-inflammatory disorders and which target dysregulated NET formation or degradation, as potential approaches that may benefit patients with severe COVID-19.
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DOI：
10.1074/jbc.m110.103275
发表时间：
2010-07-23
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Belouzard S;Madu I;Whittaker GR
通讯作者：
Whittaker GR
影响因子：
24.8
作者：
Carmona-Rivera, Carmelo;Carlucci, Philip M.;Kaplan, Mariana J.
通讯作者：
Kaplan, Mariana J.
影响因子：
158.5
作者：
Boulware, David R.;Pullen, Matthew F.;Hullsiek, Kathy H.
通讯作者：
Hullsiek, Kathy H.
影响因子：
16.6
作者：
Ali, Ramadan A.;Gandhi, Alex A.;Knight, Jason S.
通讯作者：
Knight, Jason S.
影响因子：
32.4
作者：
Adrover, Jose M.;del Fresno, Carlos;Hidalgo, Andres
通讯作者：
Hidalgo, Andres