Models wagging the dog: are circuits constructed with disparate parameters?
Models wagging the dog: are circuits constructed with disparate parameters?
复制标题
模型摇狗:电路是用不同的参数构建的吗?
DOI:
10.1162/neco.2007.19.8.1985
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发表时间:
2007
影响因子:
2.9
通讯作者:
Selverston,AllenI
中科院分区:
文献类型:
--
作者:
Nowotny,Thomas;Szucs,Attila;Levi,Rafael;Selverston,AllenI
In a recent article, Prinz, Bucher, and Marder (2004) addressed the fundamental question of whether neural systems are built with a fixed blueprint of tightly controlled parameters or in a way in which properties can vary largely from one individual to another, using a database modeling approach. Here, we examine the main conclusion that neural circuits indeed are built with largely varying parameters in the light of our own experimental and modeling observations. We critically discuss the experimental and theoretical evidence, including the general adequacy of database approaches for questions of this kind, and come to the conclusion that the last word for this fundamental question has not yet been spoken.