Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma.
Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma.
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DOI：
10.4132/koreanjpathol.2012.46.6.523
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发表时间：
2012-12
影响因子：
--
通讯作者：
Kim BH
中科院分区：
文献类型：
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作者：
Kang Y;Jung WY;Lee H;Lee E;Kim A;Kim BH
Sirtuin 1（SIRT 1）和deleted in breast cancer 1（DBC 1）被称为肿瘤抑制或启动子基因。这可能是由于它们的不同功能和与其他蛋白质的相互作用。胃腺癌是最常见的恶性肿瘤之一，但其发生机制尚不清楚。因此，我们研究了SIRT 1、DBC 1、p53和β-catenin的免疫组织化学表达与其可变临床病理特征的关系。我们从452名接受胃切除术的患者中获得样本。构建组织芯片，进行免疫组化染色。DBC 1和SIRT 1的表达与较低的组织学分级、Lauren分类的肠型、较低的pT（p<0.001）和pN分期（DBC 1，p=0.002; SIRT 1，p<0.001）相关。观察到淋巴侵袭的缺乏与SIRT 1（p=0.001）和DBC 1（p=0.004）之间的关联。胞浆β-连环蛋白表达与较低的组织学分级、pT、pN、肿瘤淋巴结转移（TNM）分期、DBC 1（p<0.001）和SIRT 1（p=0.001）相关。SIRT 1和DBC 1的表达与p53无关（p=0.063和p=0.060）。在多变量分析中，DBC 1是一个独立的良好预后因素（p=0.012）。SIRC 1和DBC 1可作为胃腺癌的良好预后因子。
Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics. We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed. Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012). SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.