Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls
Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls
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DOI：
10.1016/s0304-3940(02)00164-7
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发表时间：
2002-05-10
影响因子：
2.5
通讯作者：
Schröder, J
中科院分区：
文献类型：
--
作者：
Schönknecht, P;Lütjohann, D;Schröder, J
细胞培养实验表明，海马神经元中胆固醇的积累导致淀粉样前体蛋白加速裂解成淀粉样成分。为了从大脑中消除，胆固醇被转化为24 S-羟基胆固醇，这可能反映了大脑胆固醇的周转。我们研究了一组14名阿尔茨海默病（AD）患者和10名健康对照者的脑脊液（CSF）中24 S-羟基胆固醇的浓度，这些患者没有任何认知缺陷或精神或神经系统疾病。为了排除循环血浆胆固醇对CSF 24 S-羟基胆固醇水平的潜在影响，仅纳入胆固醇水平在150-230 mg/dl正常范围内的患者和对照。我们发现，与健康对照组相比，AD患者CSF中24 S-羟基胆固醇水平显著升高，但血浆水平无显著升高。我们的研究结果表明，CSF 24 S-羟基胆固醇在AD中增加。这种效应似乎不是由血浆胆固醇水平触发的，因为后者在组间没有显著差异。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Experiments in cell cultures indicate that accumulation of cholesterol in hippocampal neurons results in an accelerated cleavage of amyloid precursor protein into amyloidogenic components. To be eliminated from the brain, cholesterol is converted to 24S-hydroxycholesterol which may reflect cerebral cholesterol turnover. We investigated cerebrospinal fluid (CSF) concentrations of 24S-hydroxycholesterol in a group of 14 Alzheimer's disease (AD) patients and ten healthy controls without any cognitive deficits or psychiatric or neurological disorders. To exclude potential effects of circulating plasma cholesterol on CSF 24S-hydroxycholesterol levels, only patients and controls with cholesterol levels in the normal range of 150-230 mg/dl were included. We found significantly elevated 24S-hydroxycholesterol CSF but not plasma levels in AD patients compared with healthy controls. Our results demonstrate that CSF 24S-hydroxycholesterol is increased in AD. This effect does not seem to be triggered by plasma cholesterol levels since the latter did not significantly differ between groups. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.