Exploring the whereabouts of GLUT4 in skeletal muscle (review).
Exploring the whereabouts of GLUT4 in skeletal muscle (review).
复制标题
探索 GLUT4 在骨骼肌中的去向（综述）。
DOI：
10.1080/09687680110119229
复制
发表时间：
2002
影响因子：
--
通讯作者：
Ralston,Evelyn
中科院分区：
文献类型：
--
作者：
Ploug,Thorkil;Ralston,Evelyn
The glucose transporter GLUT4 is expressed in muscle, fat cells, brain and kidney. In contrast to other glucose transporters, GLUT4 in unstimulated cells is mostly intracellular. Stimuli such as insulin and muscle contractions then cause the translocation ofGLUT4 tothe cell surface. Questions related toGLUT4 storage compartments, trafficking to the surface membrane, and nature of the intracellular pools, have kept many groups busy for the past 20 years. Yet, one of the main questions in the field remains the universality of GLUT4 features. Can one extrapolate work done on fat cells to muscle or brain? Or vice-versa? Can one use cultures to predict GLUT4 behaviour in fully differentiated tissues? This review summarizes the authors' knowledge of GLUT4 biology in skeletal muscle, which is the predominant tissue for glucose homeostasis. The results are compared to those obtained withthe fatcell system, and an attemptis made to assess the universality principle.
