Pig HDL-binding protein (HDLBP) genotype is associated with intramuscular fat percentage
Pig HDL-binding protein (HDLBP) genotype is associated with intramuscular fat percentage
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DOI：
10.1016/j.livsci.2009.06.005
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发表时间：
2009-12-01
影响因子：
1.8
通讯作者：
Amills, M.
中科院分区：
文献类型：
--
作者：
Canovas, E.;Quintanilla, R.;Amills, M.
高密度脂蛋白结合蛋白（HDLBP）或vigilin是一种具有广泛功能的分子，涉及异染色质结构的维持和基因表达的调节。有证据表明HDLBP的表达受细胞内胆固醇水平的调节。此外，Vigilin在动脉粥样硬化斑块的巨噬细胞和平滑肌细胞中的表达与非病变冠状动脉内膜的表达存在差异。在这个工作。我们已经测序了猪HDLBP基因98%的编码区。序列比对使我们能够确定一个c.3120G>A同义多态性外显子23中分离的商业杜洛克种群。与血脂水平和不同的脂肪和胴体性状的关联分析的性能，使我们能够确定实验范围内的显着关联的多态性和肌内脂肪含量的胸腰最长肌（P=0.0034）。此外，我们还发现HDLBP基因型与火腿重量之间存在关联（P=0.0078）。(C)2009年由Elsevier B.V.出版
High density lipoprotein binding protein (HDLBP) or vigilin is a molecule with a broad range of functions dealing with the maintenance of heterochromatin structure and the regulation of gene expression. There is evidence that HDLBP expression is modulated by the intracellular levels of cholesterol. Moreover, vigilin is differentially expressed in the macrophages and smooth muscle cells of atherosclerotic plaques with regard to those of nondiseased coronary intima. In this work. we have sequenced 98% of the coding region of the pig HDLBP gene. Sequence alignment allowed us to identify a c.3120G>A synonymous polymorphism at exon 23 that segregated in a commercial Duroc population. Performance of an association analysis with serum lipid levels and diverse fatness and carcass traits allowed us to identify an experiment-wide significant association between this polymorphism and intramuscular fat content of longissimus thoracis et lumborum muscle (P=0.0034). Moreover, we have detected a suggestive association between HDLBP genotype and ham weight (P=0.0078). (C) 2009 Published by Elsevier B.V.