Unveiling TMEM106B: SARS-CoV-2’s secret entrance to the cell
Unveiling TMEM106B: SARS-CoV-2’s secret entrance to the cell
复制标题
揭示 TMEM106B:SARS-CoV-2 进入细胞的秘密入口
DOI:
10.1016/j.cell.2023.07.005
复制
发表时间:
2023
期刊:
影响因子:
64.5
通讯作者:
Hu, Fenghua
中科院分区:
文献类型:
--
作者:
Lacrampe, Alexander;Hu, Fenghua
The lysosomal membrane protein TMEM106B functions as a proviral factor in SARS-CoV-2 infection, though it was not known how. In this issue ofCell, Baggen et al. demonstrate that TMEM106B serves as an ACE2-independent receptor for SARS-CoV-2 entry by promoting the fusion of the viral membrane with the lysosomal membrane.