Unveiling TMEM106B: SARS-CoV-2’s secret entrance to the cell

Unveiling TMEM106B: SARS-CoV-2’s secret entrance to the cell
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揭示 TMEM106B:SARS-CoV-2 进入细胞的秘密入口

DOI:
10.1016/j.cell.2023.07.005
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发表时间:
2023
期刊:
影响因子:
64.5
通讯作者:
Hu, Fenghua
Hu, Fenghua
中科院分区:
生物学1区
文献类型:
--
作者:
Lacrampe, Alexander;Hu, Fenghua

文献摘要

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溶酶体膜蛋白TMEM106B在SARS-CoV-2感染中起原病毒因子的作用,尽管其机制尚不清楚。在这一期的cell中,Baggen等人证明TMEM106B通过促进病毒膜与溶酶体膜的融合,作为SARS-CoV-2进入的ace2非依赖性受体。
The lysosomal membrane protein TMEM106B functions as a proviral factor in SARS-CoV-2 infection, though it was not known how. In this issue ofCell, Baggen et al. demonstrate that TMEM106B serves as an ACE2-independent receptor for SARS-CoV-2 entry by promoting the fusion of the viral membrane with the lysosomal membrane.