Reproducibility of high-resolution optical coherence tomography in multiple sclerosis
Reproducibility of high-resolution optical coherence tomography in multiple sclerosis
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DOI：
10.1177/1352458510371640
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发表时间：
2010-07-01
影响因子：
5.8
通讯作者：
Calabresi, Peter A.
中科院分区：
文献类型：
--
作者：
Syc, Stephanie B.;Warner, Christina V.;Calabresi, Peter A.
光学相干断层扫描（OCT）是一种非侵入性方法，用于量化多发性硬化临床试验中神经退行性疾病的结局;然而，没有关于多发性硬化患者Cirrus谱域光学相干断层扫描（SD-OCT）再现性的数据。本研究的目的是确定使用新型高清SD-OCT对健康对照和多发性硬化症患者进行的研究的最佳访视间、评价者间和评价者内再现性的方案。Cirrus-HD SD-OCT在多发性硬化症患者（n=58）和健康对照（n=32）中的平均和象限视网膜神经纤维层（RNFL）的良好再现性厚度值、平均黄斑厚度（AMT）和总黄斑体积（TMV）[通过组内相关系数（ICC）测量]被发现用于访视间（健康对照：平均RNFL=0.97，象限范围=0.92-0.97，AMT=0.97，TMV=0.92），评分者间（MS：平均RNFL=0.97，象限=0.94-0.98，AMT=0.99，TMV=0.96;健康对照：平均RNFL=0.97，象限= 0.94-0.97，AMT=0.98，TMV=0.99），以及评价者内（MS患者：平均RNFL=0.99，象限=0.83-0.99，AMT=0.97，TMV=0.98）重现性。由Cirrus HD-OCT导出的视网膜测量的再现性，特别是象限值，是极好的。使用SD-OCT技术进行OCT采集和视网膜成像指标分析的特定程序可能会改善这种新技术在多发性硬化症中的应用。
Optical coherence tomography (OCT) is a non-invasive method to quantify neurodegeneration as an outcome in multiple sclerosis clinical trials; however, no data exist on Cirrus spectral domain optical coherence tomography (SD-OCT) reproducibility in patients with multiple sclerosis. The objective of this study was to determine the protocol for achieving optimal inter-visit, inter-rater, and intra-rater reproducibility for studies performed on healthy controls and multiple sclerosis patients utilizing novel high-definition SD-OCT. This is a prospective study of inter-visit, inter-rater, and intra-rater reproducibility in multiple sclerosis patients (n=58) and healthy controls (n=32) on Cirrus-HD SD-OCT. Excellent reproducibility of average and quadrantic retinal nerve fiber layer (RNFL) thickness values, average macular thickness (AMT), and total macular volume (TMV) [measured by intraclass correlation coefficient (ICC)] was found for inter-visit (healthy controls: mean RNFL=0.97, quadrant range=0.92-0.97, AMT=0.97, TMV=0.92), inter-rater (MS: mean RNFL=0.97, quadrant=0.94-0.98, AMT=0.99, TMV=0.96; healthy controls: mean RNFL=0.97, quadrant 0.94-0.97, AMT=0.98, TMV=0.99), and intra-rater (MS patients: mean RNFL=0.99, quadrant=0.83-0.99, AMT=0.97, TMV=0.98) reproducibility. The reproducibility of retinal measures derived by Cirrus HD-OCT, especially quadrantic values, is excellent. Specific procedures for OCT acquisition and analysis of retinal imaging metrics using SD-OCT technology may improve the application of this novel technology in multiple sclerosis.