Cooperation between the hippocampus and the entorhinal cortex in spatial memory: A disconnection study
Cooperation between the hippocampus and the entorhinal cortex in spatial memory: A disconnection study
复制标题
DOI：
10.1016/j.bbr.2006.02.006
复制
发表时间：
2006-06
影响因子：
2.7
通讯作者：
C. Parron;B. Poucet;E. Save
中科院分区：
文献类型：
--
作者：
C. Parron;B. Poucet;E. Save
最近的研究表明，包括内嗅皮质在内的海马旁区域的损伤不会破坏水迷宫中的位置学习，这表明海马皮质回路对于空间记忆并不重要[Burwell RD，Saddoris MP，Bucci DJ，Wiig KA。皮质海马对空间和情境学习的贡献。神经科学杂志 2004 年；24：3826–36]。本研究的目的是使用断开程序，在两个不同的空间任务（地点导航任务和自发物体探索任务）中更直接地对海马体和内嗅皮层之间的合作进行评估。破坏内嗅-海马系统会导致两项任务中的损伤，但仅在空间物体探索任务中，对侧病变的大鼠比同侧病变的大鼠表现出更大的缺陷。结果表明，海马体和内嗅皮层之间的合作受到任务性质和空间记忆形成所涉及的认知过程的调节。
It has been recently shown that lesions of parahippocampal areas including the entorhinal cortex do not disrupt place learning in the water maze, suggesting that the hippocampo-cortical circuitry is not important for spatial memory [Burwell RD, Saddoris MP, Bucci DJ, Wiig KA. Corticohippocampal contributions to spatial and contextual learning. J Neurosci 2004;24:3826–36]. The aim of the present study was to tax more directly the cooperation between the hippocampus and entorhinal cortex in two different spatial tasks, a place navigation task and a spontaneous object exploration task, using a disconnection procedure. Damaging the entorhinal–hippocampal system induced impairments in the two tasks but only in the spatial object exploration task rats with contralateral lesions displayed a greater deficit than rats with ipsilateral lesions. The results suggest that the cooperation between the hippocampus and the entorhinal cortex is modulated by the nature of the task and the cognitive processes involved in formation of spatial memory.