LIMBIC LESIONS AND PROBLEM OF STIMULUS-REINFORCEMENT ASSOCIATIONS
LIMBIC LESIONS AND PROBLEM OF STIMULUS-REINFORCEMENT ASSOCIATIONS
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DOI：
10.1016/0014-4886(72)90030-1
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发表时间：
1972-01-01
影响因子：
5.3
通讯作者：
MISHKIN, M
中科院分区：
文献类型：
--
作者：
JONES, B;MISHKIN, M
先前的解剖工作表明，颞下视觉皮层投射到边缘系统内或与边缘系统密切相关的三个区域：眶额皮层（OF）、颞极和杏仁核（TPA）以及梭状海马回和海马（FHH）。为了确定这些边缘投射中的哪一个可能对于视觉和其他方式中刺激强化关联的形成最重要，对这三个区域（和对照组）有损伤的猴子组进行了物体和地点辨别逆转学习的比较。虽然三种不同的边缘系统切除中的每一种都会产生损伤，但 FHH 损伤的影响仅限于位置逆转任务，而 OF 消融后的缺陷虽然是超模态的，但其特征是难以抑制刺激-强化关联。只有 TPA 病变（也是超模态）产生的损伤与形成此类关联的困难一致，考虑到同一病变后重复描述的总体行为异常，这一解释得到了加强。
Previous anatomical work has shown that the inferotemporal visual cortex projects to three regions within or closely related to the limbic system—the orbitofrontal cortex (OF), the temporal pole and amygdala (TPA), and the fusiform-hippocampal gyrus and hippocampus (FHH). To determine which of these limbic projections might be the most important for the formation of stimulus-reinforcement associations in vision and in other modalities, groups of monkeys with lesions in these three regions (and controls) were compared on both object and place discrimination reversal learning. While each of the three different limbic removals produced an impairment, the effect of the FHH lesion was limited to the place reversal task, and the deficit after the OF ablation, although supramodal, was characterized by a difficulty in the suppression of stimulus-reinforcement associations. Only the impairment produced by the TPA lesion, also supramodal, was consistent with a difficulty in the formation of such associations, an interpretation which is strengthened by a consideration of the gross behavioral abnormalities that have been described repeatedly following this same lesion.