MULTIFOCAL ADENOCARCINOMA OF THE STOMACH IN A CHILD WITH COMMON VARIABLE IMMUNODEFICIENCY
MULTIFOCAL ADENOCARCINOMA OF THE STOMACH IN A CHILD WITH COMMON VARIABLE IMMUNODEFICIENCY
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DOI：
10.1097/00005176-198805000-00025
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发表时间：
1988-05-01
影响因子：
2.9
通讯作者：
BOYLE, JT
中科院分区：
文献类型：
--
作者：
CONLEY, ME;ZIEGLER, MM;BOYLE, JT
临床过程中的一个孩子谁开发的胃腺癌在11岁的描述。在6岁时，孩子被评估为腹痛，体重减轻和呕吐。她被发现有出血性萎缩性胃炎、无氯血症和全低丙种球蛋白血症。用皮质类固醇治疗后胃炎有所改善，但每次类固醇剂量逐渐减少时都会复发。临床病程以严重生长障碍、复发性感染和间歇性腹痛为特征。当病人11岁时，放射学检查显示胃小弯有一个巨大的蕈状肿块。1年前进行的内窥镜检查和活检没有发现任何恶性肿瘤的迹象。行根治性胃切除术。显微镜检查发现多灶性胃腺癌，没有证据表明浸润粘膜下层或局部淋巴结。病人在胃切除术后6个月死于败血症和肺炎。尸检时没有肿瘤复发的证据。常见的可变免疫缺陷和胃肠道疾病之间的关系进行了描述。
The clinical course of a child who developed an adenocarcinoma of the stomach at 11 years of age is described. At 6 years of age, the child was evaluated for abdominal pain, weight loss, and vomiting. She was found to have hemorrhagic, atrophic gastritis, achlorhydria, and panhypogammaglobulinemia. The gastritis improved with corticosteroid therapy, but relapsed each time that the steroid dosage was tapered. The clinical course was marked by severe growth failure, recurrent infections, and intermittent abdominal pain. Radiographic studies done when the patient was 11 years of age demonstrated a large fungating mass on the lesser curvature of the stomach. Endoscopy and biopsies done 1 year previously had not revealed any sign of malignancy. A radical gastrcctomy was performed. Microscopic studies revealed multifocal adenocarcinoma of the stomach with no evidence of invasion of the submucosa or local lymph nodes. The patient died ofCandidasepticemia and pneumonia 6 months after the gastrectomy. There was no evidence of recurrence of the tumor on autopsy. The relationship between common variable immunodeficiency and gastrointestinal disease is described.