The HOPE (Heart Outcomes Prevention Evaluation) Study: the design of a large, simple randomized trial of an angiotensin-converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events. The HOPE study investigators.
The HOPE (Heart Outcomes Prevention Evaluation) Study: the design of a large, simple randomized trial of an angiotensin-converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events. The HOPE study investigators.
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HOPE(心脏结果预防评估)研究:针对心血管事件高危患者设计了一项针对血管紧张素转换酶抑制剂(雷米普利)和维生素 E 的大型、简单随机试验。
DOI:
10.1016/s0304-3975(03)00090-2
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发表时间:
1996
期刊:
影响因子:
--
通讯作者:
R. Mack
中科院分区:
文献类型:
--
作者:
F. Mindlen;R. Nordaby;M. Ruiz;A. Zavala;L. Guzman;F. Martinez;R. Diaz;C. Mackey;M. Marino;G. Romero;G. Zapata;C. Cuneo;T. Kawamura;O. Coelho;O. Massayochi;J. Braga;A. Labrunie;L. Bodanese;E. Manenti;D. Vitola;J. Nicolau;C. Amodeo;D. Armaganijan;M. Bertolami;B. Caramelli;A. Carvalho;C. Cirenza;M. Fichino;R. Franken;N. Ghorayeb;T. Kadri;P. Leão;F. Malheiros;R. Pavanello;F. Ramires;J. Ramires;F. Savioli;A. Sousa;L. Tanajura;D. Topps;L. Korner;Martínez;B. Baptie;M. Basinger;B. Baylis;P. Beresford;A. Edwards;P. Giannaccaro;Y. Groenewoud;M. Grose;J. Kellen;S. Lam;R. Lesoway;P. Ma;D. Meldrum;D. Mitchell;L. Mitchell;D. Roth;S. Shumak;M. Simon;J. Stone;W. Warnica;D. Wyse;C. Neffgen;J. Neffgen;F. Armstrong;W. Armstrong;N. Bell;W. Black;N. Brass;F. Brenneis;R. Brownoff;G. Chaytors;D. Debanne;C. Derksen;M. Donoff;Dzavik;M. Goeres;P. Greenwood;S. Gulamhusein;W. Hui;K. Hutchison;L. Kasian;L. Kasza;E. Krikke;L. Kvill;Z. Lakhani;D. Linklater;J. Mackel;S. Martin;T. Montague;D. Moores;A. Musseau;T. Muzyka;J. Paradis;A. Prosser;E. Ryan;M. Senaratne;P. Stenerson;T. Talibi;K. Teo;C. Young;Zuk;Roseann M. White;K. Browne;M. Browne;K. Happel;A. Irving;A. Plesko;R. Donnelly;N. Radomsky;P. Felker;D. Larsen;J. Morse;C. Rowntree;J. Thompson;R. Wedel;G. Bloomberg;G. Chomin;M. Dahl;W. Leong;Moy;J. Heath;J. Marshall;M. Terwiel;G. Kenefick;R. Kuritzky;K. Stevens;K. Weddings;K. Barban;Imrie;K. Woo;T. Ashton;K. Calvert;W. Bishop;R. Sweeney;L. Breakwell;J. Kornder;S. Pearce;P. Polasek;P. Richardson;S. Ghosh;M. Rielly;K. Wagner;Bemstein;K. Dawson;P. Lee;J. Lewis;K. MacDonald;L. McGee;C. Thompson;D. Hilton;K. Illott;P. Klinke;J. Mcconnell;S. Rabkin;A. Ong;G. Ong;D. Bedard;R. Hoeschen;P. Mehta;Mohammad;A. Morris;R. Bessoudo;N. Dobbins;L. McLellan;Milton;R. Davis;D. OKeefe;Richard Smith;C. Joyce;M. Parsons;J. Skanes;B. Sussex;M. Tobini;M. Ravalia;G. Sherman;G. Worrall;A. Atkinson;R. Hatheway;B. Johnson;S. Barnhill;Bata;J. Cosseet;D. Johnstone;M. MacFarlane;W. Sheridan;L. Crossman;D. Folkins;M. Shirley;T. Machel;J. Morash;M. Gupta;M. Mayich;T. Vakani;T. Baitz;E. Macphee;E. Turton;M. Turton;N. Chan;J. Misterski;D. Raco;G. Curnew;E. Fallen;L. Finkelstein;H. Gerstein;P. Hardman;S. Lawand;E. Lonn;W. Magi;M. McQueen;A. Panju;R. Patterson;B. Sullivan;H. Sullivan;M. Sullivan;K. G. Taylor;Worron;S. Yusuf;W. Cameron;C. Noseworthy;R. Houlden;T. Lavalle;R. Fowlis;Janzen;M. Arnold;M. Cann;S. Carroll;S. Dumaresq;M. Edmonds;P. Furlong;C. Geddes;E. Graham;K. Harris;Hramiak;R. Kennedy;W. Kostuk;M. Krupa;B. Lent;M. Lovell;C. Maclean;D. Massel;R. Mcmanus;J. Mcsherry;C. Muñoz;J. Occhipinti;L. Oosterveld;P. Pflugfelder;S. Powers;R. Southern;D. Spence;P. Squires;S. Wetmore;J. Willing;G. Wisenberg;B. Wolfe;P. Kannampuzha;T. Rebane;Sluzar;A. R. Hess;Y. Chan;D. Thomson;R. Baigrie;J. Dubbin;C. Liuni;K. Tan;E. Brankston;P. Hewson;B. Hrycyshyn;W. Kapusta;L. Knox;C. Lockner;P. Whitsitt;M. Baird;D. Conroy;R. Davies;R. Davies;M. Fraser;S. Hagar;P. Hierlihy;E. Keely;S. Khan;D. Lau;L. Marois;K. Németh;E. Reeves;M. Turek;R. Vexler;D. Young;G. Kumar;G. Kuruvilla;P. Kuruvilla;D. Lowe;K. Kwok;J. Blakely;S. Styling;B. Bożek;J. Charles;D. Fell;D. Fell;E. Goode;LD Grossman;E. Matthews;R. Nitkin;J. Ricci;A. Selby;Nina P. Singh;J. Swan;J. Emmett;M. Weingert;F. Ganjavi;D. Hill;S. Nawaz;R. Hessian;K. Kwiatkowski;C. Lai;C. Mulaisho;H. OKeefe;H. Smith;A. Weeks;J. Andrews;A. Barnie;M. Drobac;P. Hacker;A. Hanna;M. Iwanochko;A. Kenshole;A. Langer;P. Liu;S. Maclean;G. Moe;Z. Sasson;L. Sternberg;C. Trachuk;J. Walters;B. Zinman;M. Cheung;C. Cinà;L. Yao;K. Man;J. Fulop;A. Glanz;M. Sibbick;P. Carter;J. Hickey;E. McMillian;D. Dion;R. StHilaire;D. Coutu;G. DAmours;R. Starra;J. Brooks;P. Dechamps;G. Kiwan;S. Kouz;M. LaForest;C. Rémillard;D. Bellamy;R. Brossoit;S. Carrier;A. Houde;Labonte;A. Bélanger;N. Kandalaft;L. Quenneville;M. Sandi;P. Auger;N. Bilodeau;F. Delage;F. Dumont;R. Giroux;R. Loisel;C. Poirier;D. Saulnier;P. Carmichael;C. Lemay;J. Lenis;N. Aris;H. Bedard;C. Casavant;J. Chiasson;D. Dagenais;D. Fitchett;D. Gossard;H. Halle;N. Hamel;M. Joyal;O. Magnan;M. Méthé;L. Pedneault;C. Pilon;D. Poisson;L. Primeau;C. Rondeau;C. Roy;M. Ruel;A. Serpa;F. Sestier;M. Smilovitch;P. Theroux;J. Beaudoin;Boudreault;D. D'amours;T. Douville;G. Giguère;G. Houde;R. Labbe;S. Lachance;L. Lessard;G. Mercier;HP Noel;P. Talbot;J. Tremblay;A. Karabatsos;K. Maclellan;P. Wilson;P. Bogaty;D. LaForge;M. Langlais;M. Leblanc;M. Samson;J. Turcotte;J. Campeau;R. Dupuis;C. Lauzon;F. Ouimet;G. Pruneau;C. Desmaris;Frechetto;P. Gervais;J. Brophy;S. Leroux;S. Bester;L. Meunier;M. Sayeed;M. Hart;Moumne;G. Thomasse;J. Walker;M. Walker;S. Ahmed;N. Habib;P. Kuny;J. López;W. Klein;M. Grisold;L. Heyndrickx;A. Fiasse;J. Degaute;J. Mockel;D. Duprez;J. Chaudron;A. Bodson;G. Krzentowski;J. Boland;K. Kølendorf;B. Winther;H. Juhl;T. Hamalainen;O. Siitonen;H. Gin;Rigalleau;J. Hensen;R. Riel;R. OehmenBritsch;B. Schulze;R. Hopf;A. M. Møller;C. Rosak;H. Wetzel;C. Hasslacher;T. Martin;J. Stein;E. Erdmann;M. Böhm;D. Hartmann;M. Breidert;R. Fritzen;W. Scherbaum;J. Mann;J. Maus;C. Schroeder;H. Henrichs;H. Unger;G. Ickenstein;E. Kromer;G. Riegger;H. Schunkert;B. Basan;R. Hampel;P. Crean;T. Garadah;U. White;N. Marini;E. Paciaroni;G. Saccomano;S. Diluzio;B. Magnani;B. Mantovani;P. Pareschi;N. Stucchi;D. Nanni;F. Rusticali;C. Simoni;C. Brunelli;S. Caponnetto;E. Gatto;A. Mazzantini;O. Molinari;R. Morello;L. Degiorgio;C. Imparato;F. Barbaresi;A. Cotogni;M. Pasqualini;G. Frigeni;M. Landoni;A. Polese;A. Cernigoi;M. Merni;C. Tortul;M. Velussi;F. Aina;C. Cernigliaro;P. Dellavesa;U. Dejoannon;G. Pierfranceschi;D. Zavaroni;R. Emilia;E. Manicardi;E. Minelli;F. Penazzoli;Portioli;E. Rossi;P. Giani;R. Roccaforte;M. Casaccia;R. Larovere;E. Miglierina;S. Repetto;P. Centofante;M. Vincenzi;A. Nieuwenhuijzen;J. Sels;B. Wolffenbuttel;J. Kip;L. Mantingh;H. Mulder;L. Vandoorn;E. Hjerkinn;Å. Reikvam;M. Cardona;G. Sanz;A. Karoni;LL Bescos;Albert;R. Masiá;Á. Álvarez;L. Sáenz;L. Astrom;R. Press;P. Sjostedt;F. Tabrizi;Bergbom;P. Hansson;C. Held;T. Kahan;B. Ryden;O. Andersson;M. Wysocki;E. Karlsson;G. Sartor;L. Smith;P. Katzman;L. Ljungdahl;P. Norén;A. Hallberg;P.‐O. Olsson;S. Åsbrink;J. Mølgaard;Nilsson;F. Nystrom;P. Ohman;C. Andersson;L. Ekholm;K. Svensson;E. Torebo;B. Fagher;Svenstam;T. Thulin;U. Ericsson;K. Ahnberg;R. Henning;L. Jacobsson;A. Taghavi;P. Ahlstrom;U. Rosenqvist;C. Ericson;O. Gertow;BE Kristensson;L. Stahl;L. Bergsten;R. Harden;C. Jagren;B. Leijd;P. Lennerhagen;J. Ostergrens;Sandstrom;R. Sundelin;A. Hagg;C. Morlin;F. Pettersson;A. Wanders;H. Bjorkman;G. Karlsson;H. Larsson;Y. Lonndahl;P. Weber;R. Cozzi;P. Gerber;T. Moccetti;E. Safwan;F. Sessa;T. Binder;P. Boman;W. Kiowski;R. Lehman;B. Lull;G. Spinas;A. Jamieson;J. Kennedy;C. Kesson;R. Gryczka;P. Parker;S. Sidiki;M. Small;S. Struthers;J. Manns;H. Smithurst;A. Begg;B. Fisher;C. Bedford;S. Heller;S. Marlow;Ernesto German Cordona Munoz;HH Garcia;Rogerio M. Ruiz;E. Meaney;Miranda Flores;E. Brown;G. Perry;G. Patel;R. J. Sarma;Y. Szlachcic;J. Dorman;B. N. Singh;G. Bailey;L. Clegg;L. Horwitz;J. Leahy;A. Rashkow;M. Hudson;A. Miller;J. Umberger;R. Zoble;P. Orander;M. R. Sridharan;G. DeFrancisco;M. Davidson;N. Islam;J. Mathew;R. Rajanahally;D. French;W. Wickemeyer;M. Effron;M. Goldstein;K. Utley;G. Pierpont;J. Weigenant;M. Farkouh;Kubly;M. Rich;L. Wisneski;J. Abrams;D. Garcia;M. Bonora;R. Kohn;E. Muffoletto;D. Brink;E. Lader;A. Singler;P. Pande;J. Powers;B. Hoogwerf;J. Moore;F. Yanak;S. Gupta;D. Williams;K. Danisa;C. Kirk;B. Wescott;J. Grover;M. Mackenzie;M. Amidi;M. Bell;J. Farmer;C. Kingry;J. Young;Harms;J. Kennedy;R. Letterer;C. Heller;R. Mack
OBJECTIVE
To describe the design of the HOPE (Heart Outcomes Prevention Evaluation) study.
DESIGN
Description of the key design features of HOPE, a large, simple randomized trial of two widely applicable treatments--ramipril, an angiotensin-converting enzyme inhibitor; and vitamin E, a naturally occurring antioxidant vitamin--in the prevention of myocardial infarction, stroke or cardiovascular death.
SETTING
Two-hundred and sixty-seven hospitals, physician offices and clinics in Canada, the United States, Mexico, Europe and South America.
PATIENTS
Over 9000 women and men aged 55 years and above at high risk for cardiovascular events such as myocardial infarction and stroke were recruited over 18 months.
INTERVENTIONS
A 2X2 factorial design with ramipril and vitamin E with follow-up for up to four years.
CONCLUSIONS
HOPE will be one of the largest trials of two new interventions to prevent myocardial infarction, stroke or cardiovascular death in high risk patients. The results of HOPE will have direct public health impact and are likely to be readily incorporated into clinical practice. Key design features of HOPE are inclusion of individuals at high risk of cardiovascular disease, inclusion of a substantial proportion of patients with diabetes (36%) and women (27%), and detailed substudies to provide data on mechanisms of benefit.