Interpretation of circulating C-reactive protein levels in adults:: Body mass index and gender are a must
Interpretation of circulating C-reactive protein levels in adults:: Body mass index and gender are a must
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DOI：
10.1016/s1262-3636(07)70019-8
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发表时间：
2003-04-01
影响因子：
7.2
通讯作者：
Jardel, C
中科院分区：
文献类型：
--
作者：
Piéroni, L;Bastard, JP;Jardel, C
目的：最近发现的c反应蛋白（CRIP）水平与身体质量指数（BMI）之间的关系提出了CRP与肥胖程度之间的关系问题。在本研究中，我们在一个健康人群中测量了CRP， BMI范围很广，以便了解超重对临床使用中CRP结果解释的影响。方法：研究对象为献血者，年龄19 ~ 65岁。根据BMI将受试者分为3组：A组（BMI < 25 kg/m 2, n = 611）；B (25-30, n = 147)；C （bbb30, n = 34）。结果：CRP值在男女之间存在差异。在女性中，CRP随着BMI的增加而逐渐增加。这些结果清楚地表明，CRP的平均水平因受试者的BMI和性别而有较大差异，并产生了不同的正常CRP表达范围（mg/L）（中位数，第75（th）百分位）：A组：女性：0.44,0.93；男子：0.40,0.79，B组：女子：1.28,1.84；男子：0.84、2.17；C组女子：3.61、7.21；男子：1.16分，3.08分。结论：我们的结果表明，对于炎症性疾病的诊断，5 mg/L的CRP浓度对肥胖女性来说是正常的，但对正常人来说是75（th）百分位数的5倍。
Objective: The recently demonstrated association between C-reactive protein (CRIP) level and body mass index (BMI) raised the question of the link between CRP and the degree of obesity. In the present study, we measured CRP in a healthy population with a wide range of BMI in order to appreciate the influence of overweight in the interpretation of CRP results in clinical use.Method: Blood donors, aged from 19 to 65 years, were included in the study. According to BMI, subjects were classified into 3 groups: A (BMI < 25 kg/m(2), n = 611); B (25-30, n = 147); C (> 30, n = 34).Results: CRP values were different among women and men. CRP progressively increased with BMI in women. These results clearly showed that average level of CRIP was quite different according to BMI and gender of the subjects and generated different normal ranges of CRP expressed in mg/L (median, 75(th) percentile): Group A: women: 0.44, 0.93; men: 0.40, 0.79, Group B: women: 1.28, 1.84; men: 0.84, 2.17, Group C: women: 3.61, 7.21; men: 1.16, 3.08.Conclusion: Our results suggest that for an inflammatory disease diagnosis, a CRP concentration of 5 mg/L is normal for obese women but is five times the 75(th) percentile for normal people.