Minocycline increases quality and longevity of chronic neural recordings
Minocycline increases quality and longevity of chronic neural recordings
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DOI：
10.1088/1741-2560/4/2/l01
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发表时间：
2007-06-01
影响因子：
4
通讯作者：
Wilson, D. A.
中科院分区：
文献类型：
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作者：
Rennaker, R. L.;Miller, J.;Wilson, D. A.
脑/机接口可能用于治疗从瘫痪到感觉障碍的一系列神经系统疾病。将慢性微电极阵列插入神经组织中会引发大量免疫反应，这通常会导致植入物周围形成细胞鞘，从而导致有用信号的丢失。米诺环素已被证明在某些神经损伤和神经退行性疾病模型中具有神经保护和神经恢复作用。本研究探讨了米诺环素管理的质量和寿命的慢性多通道微丝神经植入物植入后一周和一个月的听觉皮层的影响。米诺环素组的平均信噪比在第一周结束时稳定，并在随后的3周内保持在4.6以上。对照组的信噪比在整个研究期间下降，在4周结束时为2.6。此外，米诺环素组68%的电极在第4周显示出显著的刺激驱动活动，而对照组为12.5%。米诺环素受试者中植入物周围活化星形胶质细胞的数量显著减少，并且在1周和4周时活化星形胶质细胞占据的总面积减少。
Brain/machine interfaces could potentially be used in the treatment of a host of neurological disorders ranging from paralysis to sensory deficits. Insertion of chronic micro-electrode arrays into neural tissue initiates a host of immunological responses, which typically leads to the formation of a cellular sheath around the implant, resulting in the loss of useful signals. Minocycline has been shown to have neuroprotective and neurorestorative effects in certain neural injury and neurodegenerative disease models. This study examined the effects of minocycline administration on the quality and longevity of chronic multi-channel microwire neural implants I week and I month post-implantation in auditory cortex. The mean signal-to-noise ratio for the minocycline group stabilized at the end of week I and remained above 4.6 throughout the following 3 weeks. The control group signal-to-noise ratio dropped throughout the duration of the study and at the end of 4 weeks was 2.6. Furthermore, 68% of electrodes from the minocycline group showed significant stimulus-driven activity at week 4 compared to 12.5% of electrodes in the control group. There was a significant reduction in the number of activated astrocytes around the implant in minocycline subjects, as well as a reduction in total area occupied by activated astrocytes at 1 and 4 weeks.