Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nurses.
Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nurses.
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牛皮癣与糖尿病和高血压的风险：一项针对美国女护士的前瞻性研究。
DOI：
10.1001/archdermatol.2009.48
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发表时间：
2009-04
影响因子：
--
通讯作者：
Curhan, Gary C.
中科院分区：
文献类型：
--
作者：
Qureshi, Abrar A.;Choi, Hyon K.;Setty, Arathi R.;Curhan, Gary C.
为了前瞻性地评估牛皮癣与糖尿病和高血压风险之间的独立关系，一项对1991-2005年护士健康研究II的女护士的前瞻性研究，1991年有116,671名年龄在27 - 44岁的美国女性，其中78,061名女性在2005年回答了关于医生诊断的牛皮癣的终生病史的问题；在基线时报告诊断为糖尿病或高血压的妇女被排除在外，从两年一次的问卷调查中获得糖尿病或高血压的新诊断。在78,061名妇女中，1,813名（2.3%）报告诊断为牛皮癣。在14年的随访中，我们共记录了1560例（2%）糖尿病病例和15724例（20%）高血压病例。与没有牛皮癣的女性相比，患有牛皮癣的女性患糖尿病的多变量调整相对危险度（RR）为1.63 （95% CI, 1.25-2.12）。患有牛皮癣的女性患高血压的风险也增加（多变量RR为1.17；95% CI为1.06-1.30）。年龄、体重指数和吸烟没有显著改变牛皮癣与糖尿病或高血压风险之间的关系（相互作用的p值≥0.07）。在这项前瞻性分析中，牛皮癣与糖尿病和高血压风险增加独立相关。未来的研究需要检验牛皮癣治疗是否会降低糖尿病和高血压的风险。
Psoriasis has been associated with diabetes and hypertension in previous cross-sectional studies To evaluate prospectively the independent association between psoriasis and risk of diabetes and hypertension A prospective study of female nurses followed from 1991-2005 Nurses' Health Study II, a cohort of 116,671 US women aged 27 - 44 in 1991 78,061 women who responded to a question about life-time history of physician-diagnosed psoriasis in 2005; women reporting a diagnosis of diabetes or hypertension at baseline were excluded New diagnosis of diabetes or hypertension, obtained from biennial questionnaires. Among the 78,061 women, 1,813 (2.3%) reported a diagnosis of psoriasis. During the 14 years of follow-up, we documented a total of 1,560 (2%) incident cases of diabetes and 15,724 (20%) incident cases of hypertension. The multivariate-adjusted relative risk (RR) of diabetes in women with psoriasis compared to women without was 1.63 (95% CI, 1.25-2.12). Women with psoriasis were also at an increased risk for developing hypertension (multivariate RR 1.17; 95% CI, 1.06-1.30). Age, body mass index and smoking did not significantly modify the association between psoriasis and risk of diabetes or hypertension (p values for interaction ≥0.07). In this prospective analysis, psoriasis was independently associated with an increased risk of diabetes and hypertension. Future studies are needed to examine if psoriasis treatment will reduce the risk of diabetes and hypertension.
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