Analysis of intrathoracic tumor mobility during whole breathing cycle by dynamic MRI
Analysis of intrathoracic tumor mobility during whole breathing cycle by dynamic MRI
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DOI：
10.1016/j.ijrobp.2003.12.035
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发表时间：
2004-07-15
影响因子：
7
通讯作者：
Kauczor, HU
中科院分区：
文献类型：
--
作者：
Plathow, C;Ley, S;Kauczor, HU
目的：使用动态MRI评估整个呼吸周期中膈肌、肺区域和肿瘤的活动性。一个广义的放射治疗计划的安全范围的概念进行计算和比较与个性化的concept.Methods和材料：20例孤立性肺肿瘤（15个I期非小细胞肺癌，5个小的孤立性转移瘤）的呼吸周期进行了检查与动态MRI（真正的快速成像，稳定的精度，每秒三个图像）。深吸气和呼气位置的隔膜，上，中，下肺区域，和肿瘤进行了三维测量。比较了荷瘤区和相应的无瘤区的移动性。安静呼吸时的肿瘤移动性作为基于MRI的安全裕度概念。结果：肺区域的运动在下部区域比上部区域显著更大（5 +/-2切割vs. 0.9 +/-0.4 cm，p < 0.05）。肺肿瘤区的活动性明显低于相应的非受累区（p < 0.05）。在安静的呼吸，肿瘤的流动性表现出很高的变异性，3.4 mm的安全边界在上部，4.5 mm的中间，和7.2 mm的下部regions.Conclusion：动态MRI是一种简单的，非侵入性的方法来评估胸内肿瘤的流动性治疗规划。由于肿瘤移动性的高度变异性，建议采用个体安全范围。(C)2004爱思唯尔公司
Purpose: To assess diaphragm, lung region, and tumor mobility during the whole breathing cycle using dynamic MRI. A generalized safety margin concept for radiotherapy planning was calculated and compared with an individualized concept.Methods and Materials: The breathing cycles of 20 patients with solitary lung tumors (15 Stage I non-small-cell lung carcinoma, 5 small solitary metastases) were examined with dynamic MRI (true Fast imaging with steady precision, three images per second). The deep inspiratory and expiratory positions of the diaphragm, upper, middle, and lower lung regions, and the tumor were measured in three dimensions. The mobility of tumor-bearing and corresponding tumor-free regions was compared. Tumor mobility in quiet respiration served as an MRI-based safety margin concept.Results: The motion of the lung regions was significantly greater in the lower regions than in the upper regions (5 +/- 2 cut vs. 0.9 +/- 0.4 cm, p < 0.05). Tumor-bearing lung regions showed a significantly lower mobility than the corresponding noninvolved regions (p < 0.05). In quiet respiration, tumor mobility showed a high variability; a safety margin of 3.4 mm in the upper, 4.5 mm in the middle, and 7.2 mm in the lower region was calculated.Conclusion: Dynamic MRI is a simple, noninvasive method to evaluate intrathoracic tumor mobility for therapy planning. Because of the high variability of tumor mobility, an individual safety margin is recommended. (C) 2004 Elsevier Inc.