Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma
Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma
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DOI：
10.1016/j.anndiagpath.2019.06.011
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发表时间：
2019-10-01
影响因子：
2
通讯作者：
Ding, Jinhui
中科院分区：
文献类型：
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作者：
Cheng, Wei;Zhang, Bin;Ding, Jinhui
虽然有几条证据表明，死亡蛋白与恶性肿瘤的生存有关，但几乎没有描述其在肝细胞癌（HCC）中表达的预后参与。为了解Mortalin表达的预后意义，本研究采用免疫组化方法观察90例HCC组织芯片及其配对正常对照点上Mortalin的免疫组化特征，并结合临床病理变量进行详细的统计学分析，包括性别、年龄、肿瘤大小、分化程度、肝硬化、血管浸润、临床分期、T分类与肝内转移。同时绘制Kaplan-Meier生存曲线，分析Mortalin高表达与低表达患者的预后差异。Mortalin在肝癌组织中的表达明显高于正常对照组，且与肿瘤血管浸润、临床分期及肝内转移密切相关。Kaplan-Meier生存分析显示Mortalin与总生存期和无病生存期显著相关。多因素考克斯回归分析显示，Mortalin表达是影响HCC预后的独立因素。总的来说，我们提供的数据支持Mortalin在HCC中的预后预测价值。
Although several lines of evidence existed suggesting that Mortalin was linked with survival in malignant tumors; it has been barely described regarding the prognostic involvement of its expression in hepatocellular carcinoma (HCC). Herein, to understand the prognostic meaning of Mortalin expression, Immunohistochemistry was undertaken to observe the immunohistochemical characteristics of Mortalin on HCC tissue microarray consisting of 90 cases of HCC and its paired normal control dots, followed by detailed statistical analysis with the accompanying clinicopathological variables available, including gender, age, tumor size, differentiation, cirrhosis, vascular invasion, clinical stage, T classification and intrahepatic metastases. Meanwhile, Kaplan-Meier survival curve was plotted to analyze the prognostic difference for patients with high and low expression of Mortalin. It was exhibited that Mortalin was over-expressed in HCC tissues relative to paired normal control and elevated Mortalin significantly correlated with vascular invasion, clinical stage and intrahepatic metastasis. Kaplan-Meier survival analysis revealed that Mortalin was remarkably associated with overall survival and disease-free survival. Multivariate Cox regression analysis showed that expression of Mortalin was an independent prognostic factor in HCC. Collectively, the data we provided here support the prognostic prediction value of Mortalin in HCC.