S-sulfhydration as a cellular redox regulation.
S-sulfhydration as a cellular redox regulation.
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DOI：
10.1042/bsr20150147
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发表时间：
2015-11-25
影响因子：
4
通讯作者：
Włodek L
中科院分区：
文献类型：
--
作者：
Iciek M;Kowalczyk-Pachel D;Bilska-Wilkosz A;Kwiecień I;Górny M;Włodek L
本文综述了过硫化物（s -硫化）的形成及其生物学意义。介绍了活性硫的生物成因、性质及其在氧化还原信号传导中的作用。讨论了巯基水化对蛋白质功能的影响。多年来，活性氧和活性氮（ROS和RNS）被认为是巯基氧化还原调控过程中的关键信使。最近，文献报道开始提到活性硫物种（RSS）及其在硫醇调节中的作用。本文综述了RSS的生物成因和生物学特性，包括：氢过硫化物、多硫化物和硫化氢（H2S）。根据最新的文献资料，介绍了s -磺化过程的生物学意义。在这个反应中，硫烷被转移到sh基团上，形成过硫化物。被称为“氧化还原开关”的蛋白质半胱氨酸残基易受这种可逆修饰的影响。与最近的报道一致，强调含硫化合物（主要是过硫化氢和多硫化氢）是比H2S更好的s -巯基信号介质。我们还概述了参与RSS形成和运输以及线粒体H2S氧化的蛋白质。此外，我们还回顾了许多与硫代谢无关的蛋白质被s -巯基化修饰从而影响其催化活性的报道。我们还讨论了s -巯基化反应在激活KATP通道（血管松弛剂）和转录因子（如NFκB）中的调节功能，以及大蒜衍生硫化合物的治疗作用机制。本文还讨论了RNS和RSS的一些比较。
This review is focused on formation and biological significance of hydropersulfides, i.e. S-sulfhydration process. Biogenesis and properties of reactive sulfur species and their role in redox signaling are presented. The effect of S-sulfhydration on protein function is discussed. For many years reactive oxygen and nitrogen species (ROS and RNS) have been recognized as key messengers in the process of thiol-based redox regulation. Relatively recently, literature reports began to mention reactive sulfur species (RSS) and their role in thiol regulation. This review is focused on biogenesis and biological properties of RSS, including: hydropersulfides, polysulfides and hydrogen sulfide (H2S). Based on the most up-to-date literature data, the paper presents biological significance of S-sulfhydration process. In this reaction, sulfane sulfur is transferred to the–SH groups forming hydropersulfides. Protein cysteine residues, called ‘redox switches’ are susceptible to such reversible modifications. In line with the most recent reports, it was emphasized that sulfane sulfur-containing compounds (mainly hydrogen persulfides and polysulfides) are real and better mediators of S-sulfhydration-based signalling than H2S. We also overviewed proteins participating in the formation and transport of RSS and in mitochondrial H2S oxidation. In addition, we reviewed many reports about proteins unrelated to sulfur metabolism which are modified by S-sulfhydration that influences their catalytic activity. We also addressed the problem of the regulatory function of S-sulfhydration reaction in the activation of KATP channels (vasorelaxant) and transcription factors (e.g. NFκB) as well as in the mechanism of therapeutic action of garlic-derived sulfur compounds. Some aspects of comparison between RNS and RSS are also discussed in this review.