Evidence for specific suppression in the maintenance of immunologic tolerance.
Evidence for specific suppression in the maintenance of immunologic tolerance.
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DOI：
10.1084/jem.141.3.635
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发表时间：
1975-03-01
期刊：
影响因子：
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通讯作者：
Benjamin DC
中科院分区：
文献类型：
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作者：
Benjamin DC
小鼠体内已证实特异性抑制细胞对胸腺依赖性抗原 HGG 具有耐受性。将正常胸腺细胞、正常脾细胞或免疫脾细胞转移到这些耐受小鼠体内并没有恢复 HGG 的免疫能力。此外，将耐受的脾细胞转移到正常受体中消除了这些受体对随后免疫原性 HGG 攻击的反应。在诱导耐受后 5、8 或 11 周从小鼠体内取出的脾细胞特异性地抑制了过继性细胞转移系统中正常脾细胞的反应。抑制的程度似乎取决于诱导耐受后多长时间将细胞从耐受的供体中取出以及转移后多久对受体进行攻击。
Specific suppressor cells have been demonstrated in mice tolerant to the thymus-dependent antigen HGG. Transfer of normal thymocytes, normal spleen cells, or immune spleen cells into these tolerant mice did not restore immunocompetence to HGG. Furthermore, the transfer of tolerant spleen cells into normal recipients abrogated the response of these recipients to subsequent challenge with immunogenic HGG. Spleen cells removed from mice 5, 8, or 11 wk after the induction of tolerance specifically suppressed the response of normal spleen cells in an adoptive cell transfer system. The extent of suppression appears to be dependent upon how long after the induction of tolerance the cells were removed from the tolerant donors and how soon after transfer the recipients were challenged.