Ambient black carbon particles reach the fetal side of human placenta
Ambient black carbon particles reach the fetal side of human placenta
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DOI：
10.1038/s41467-019-11654-3
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发表时间：
2019-09-17
影响因子：
16.6
通讯作者：
Nawrot, Tim S.
中科院分区：
文献类型：
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作者：
Bove, Hannelore;Bongaerts, Eva;Nawrot, Tim S.
有人提出颗粒会穿过胎盘，但迄今为止，在现实生活中，人类环境中还没有直接证据存在。在这里，我们使用飞秒脉冲照明下的白光生成报告了人类胎盘中燃烧衍生颗粒物的一部分黑碳（BC）颗粒的存在。在所有筛查的胎盘中均发现了 BC，低暴露母亲和高暴露母亲的平均 (SD) 颗粒计数分别为每毫米 (3) 0.95 x 10(4) (0.66 x 10(4)) 和 2.09 x 10(4) (0.9 x 10(4)) 颗粒。此外，胎盘BC负荷与母亲在怀孕期间居住的BC暴露呈正相关（0.63-2.42ug/m(3)）。我们发现BC颗粒积聚在胎盘的胎儿一侧，这表明环境颗粒物可以被输送到胎儿，并且代表了解释生命早期污染对健康有害影响的潜在机制。
Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-derived particulate matter in human placentae using white-light generation under femtosecond pulsed illumination. BC is identified in all screened placentae, with an average (SD) particle count of 0.95 x 10(4) (0.66 x 10(4)) and 2.09 x 10(4) (0.9 x 10(4)) particles per mm(3) for low and high exposed mothers, respectively. Furthermore, the placental BC load is positively associated with mothers' residential BC exposure during pregnancy (0.63-2.42 lug per m(3)). Our finding that BC particles accumulate on the fetal side of the placenta suggests that ambient particulates could be transported towards the fetus and represents a potential mechanism explaining the detrimental health effects of pollution from early life onwards.