Graph Theoretical Analysis of Structural Neuroimaging in Temporal Lobe Epilepsy with and without Psychosis.
Graph Theoretical Analysis of Structural Neuroimaging in Temporal Lobe Epilepsy with and without Psychosis.
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DOI：
10.1371/journal.pone.0158728
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Sato N
中科院分区：
文献类型：
--
作者：
Sone D;Matsuda H;Ota M;Maikusa N;Kimura Y;Sumida K;Yokoyama K;Imabayashi E;Watanabe M;Watanabe Y;Okazaki M;Sato N
精神病是颞叶癫痫（TLE）最重要的精神共病之一，其病理生理机制至今尚未完全阐明。我们的目的是探索TLE与精神病之间的结构神经影像学的连接性差异，使用图论分析，这是一种新兴的数学方法来研究大脑中的网络连接作为一个小世界系统。我们招募了11名患有单侧海马硬化症（HS）的TLE患者，他们表现为精神病或有精神病史（TLE-P组）。作为对照，15例TLE患者单侧HS没有任何精神病发作史也招募（TLE-N组）。对于图论分析，对两组的归一化灰质图像进行图形分析（GAT）。作为次要分析，将每组与14名年龄和性别匹配的健康受试者进行比较。TLE-N组的中枢淋巴结主要位于同侧半球，TLE-P组的中枢淋巴结主要位于对侧半球。与TLE-N组相比，TLE-P组表现出更高的特征路径长度、传递性、更低的全局效率以及对随机或有针对性攻击的弹性。中间性中心性的区域比较显示，TLE-P组对侧颞叶、同侧额中回和双侧中央后回的连通性显著降低。健康受试者表现出良好的平衡节点/边缘分布，TLE-N组相似的指标，除了更高的小世界性/模块性/重复性，以及区域介数/聚类的各种差异。在TLE与精神病，图形理论分析的结构成像显示中断连接在对侧半球。网络度量表明，精神病的存在会导致全脑网络的脆弱性和效率降低。形态上同质的群体之间的结构网络的急剧差异是显着的，可能有助于更好地了解精神病在TLE。
Psychosis is one of the most important psychiatric comorbidities in temporal lobe epilepsy (TLE), and its pathophysiology still remains unsolved. We aimed to explore the connectivity differences of structural neuroimaging between TLE with and without psychosis using a graph theoretical analysis, which is an emerging mathematical method to investigate network connections in the brain as a small-world system. We recruited 11 TLE patients with unilateral hippocampal sclerosis (HS) presenting psychosis or having a history of psychosis (TLE-P group). As controls, 15 TLE patients with unilateral HS without any history of psychotic episodes were also recruited (TLE-N group). For graph theoretical analysis, the normalized gray matter images of both groups were subjected to Graph Analysis Toolbox (GAT). As secondary analyses, each group was compared to 14 age- and gender-matched healthy subjects. The hub node locations were found predominantly in the ipsilateral hemisphere in the TLE-N group, and mainly on the contralateral side in the TLE-P group. The TLE-P group showed significantly higher characteristic path length, transitivity, lower global efficiency, and resilience to random or targeted attack than those of the TLE-N group. The regional comparison in betweenness centrality revealed significantly decreased connectivity in the contralateral temporal lobe, ipsilateral middle frontal gyrus, and bilateral postcentral gyri in the TLE-P group. The healthy subjects showed well-balanced nodes/edges distributions, similar metrics to TLE-N group except for higher small-worldness/modularity/assortativity, and various differences of regional betweenness/clustering. In TLE with psychosis, graph theoretical analysis of structural imaging revealed disrupted connectivity in the contralateral hemisphere. The network metrics suggested that the existence of psychosis can bring vulnerability and decreased efficiency of the whole-brain network. The sharp differences in structural networks between morphologically homogeneous groups are remarkable and may contribute to a better understanding of psychosis in TLE.