Differences in radiation-induced heart dysfunction in male versus female rats.
Differences in radiation-induced heart dysfunction in male versus female rats.
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DOI：
10.1080/09553002.2023.2194404
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发表时间：
2023
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
放射治疗仍然是乳腺癌、肺癌和食管癌标准治疗的一部分。虽然放射治疗可以改善局部控制和生存率，但放射性心脏功能障碍是胸部放射治疗的常见副作用。心血管功能障碍也可由非治疗性全身辐射照射引起。许多研究评估了心脏辐射剂量与心脏毒性之间的关系，但对辐射诱发的心脏功能障碍（RIHD）是否存在基于生物性别的差异知之甚少。我们评估了使用1.5 cm射束大小的24戈伊单次部分递送至整个心脏后，雄性和雌性近交系Dahl SS大鼠是否显示RIHD差异。我们还比较了男性中2.0 cm与1.5 cm准直器。测量胸膜和心包积液和标准化心脏重量，并进行超声心动图检查。相对于年龄匹配的SS雄性大鼠，雌性SS大鼠表现出更严重的RIHD。雌性动物的标准化心脏重量显著增加，但雄性动物未增加。放疗结束后5个月生存率男性为94%（15/16），女性为55%（6/11）（P<0.01）。在存活大鼠中，100%的雌性和14%的雄性在5个月时出现中度至重度心包积液。雌性动物显示胸腔积液增加，雌性和雄性动物的平均标准化胸腔积液量分别为56.6 mL/kg±12.1和10.96 mL/kg±6.4（P=0.001）。超声心动图结果显示心力衰竭的证据，这在女性中更为明显。由于年龄匹配的雌性大鼠的肺较小，因此使用相同的射束大小，雌性大鼠接受辐射治疗的总肺百分比高于雄性大鼠。在雄性动物中使用较大的2 cm射束（导致肺暴露量较高）后，雄性和雌性动物在中度至重度心包积液或胸腔积液的发生方面无显著差异。用2 cm射束治疗雄性动物，导致LV质量增加和每搏输出量减少。总之，这些结果表明，雄性和雌性SS大鼠之间的辐射诱导的心脏毒性存在差异，并增加了肺辐射剂量可能在心脏辐射暴露后的心脏功能障碍中发挥重要作用的数据。这些因素可能是重要的因素纳入未来的缓解研究辐射引起的心脏毒性。
Radiation therapy remains part of the standard of care for breast, lung, and esophageal cancers. While radiotherapy improves local control and survival, radiation-induced heart dysfunction is a common side effect of thoracic radiotherapy. Cardiovascular dysfunction can also result from non-therapeutic total body radiation exposures. Numerous studies have evaluated the relationship between radiation dose to the heart and cardiotoxicity, but relatively little is known about whether there are differences based on biological sex in radiation-induced heart dysfunction (RIHD). We evaluated whether male and female inbred Dahl SS rats display differences in RIHD following delivery of 24 Gy in a single fraction to the whole heart using a 1.5 cm beam-size. We also compared 2.0 cm vs. 1.5 cm collimator in males. Pleural and pericardial effusions and normalized heart weights were measured, and echocardiograms were performed. Female SS rats displayed more severe RIHD relative to age-matched SS male rats. Normalized heart weight was significantly increased in females, but not in males. A total of 94% (15/16) of males and 55% (6/11) of females survived 5 months after completion of radiotherapy (P<0.01). Among surviving rats, 100% of females and 14% of males developed moderate-to-severe pericardial effusions at 5 months. Females demonstrated increased pleural effusions, with the mean normalized pleural fluid volume for females and males being 56.6 mL/kg±12.1 and 10.96 mL/kg±6.4 in males (P=0.001), respectively. Echocardiogram findings showed evidence of heart failure, which was more pronounced in females. Because age-matched female rats have smaller lungs, a higher percentage of total lung was treated with radiation in females than males using the same beam size. After using a larger 2 cm beam in males which results in higher lung exposure, there was not a significant difference between males and females in terms of development of moderate-to-severe pericardial effusions or pleural effusions. Treatment of males with a 2 cm beam resulted in comparable increases in LV mass and reductions in stroke volume. Together, these results illustrate that there are differences in radiation-induced cardiotoxicity between male and female SS rats and add to data that lung radiation doses may play an important role in cardiac dysfunction following heart radiation exposure. These factors may be important to factor into future mitigation studies of radiation-induced cardiotoxicity.
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DOI：
10.1161/hypertensionaha.113.01194
发表时间：
2013-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Cowley AW Jr;Ryan RP;Kurth T;Skelton MM;Schock-Kusch D;Gretz N
通讯作者：
Gretz N
影响因子：
158.5
作者：
Darby, Sarah C.;Ewertz, Marianne;Hall, Per
通讯作者：
Hall, Per
影响因子：
51.1
作者：
Bradley, Jeffrey D.;Paulus, Rebecca;Komaki, Ritsuko;Masters, Gregory;Blumenschein, George;Schild, Steven;Bogart, Jeffrey;Hu, Chen;Forster, Kenneth;Magliocco, Anthony;Kavadi, Vivek;Garces, Yolanda I.;Narayan, Samir;Iyengar, Puneeth;Robinson, Cliff;Wynn, Raymond B.;Koprowski, Christopher;Meng, Joanne;Beitler, Jonathan;Gaur, Rakesh;Curran, Walter, Jr.;Choy, Hak
通讯作者：
Choy, Hak
影响因子：
2.3
作者：
Desai, Nina;Currey, Adam;Bergom, Carmen
通讯作者：
Bergom, Carmen
DOI：
10.1016/j.ijrobp.2006.01.052
发表时间：
2006-07-15
影响因子：
7
作者：
Chang, Joe Y.;Zhang, Xiaodong;Cox, James D.
通讯作者：
Cox, James D.