Cognitive decline and Japanese culture in a cohort of older Japanese Americans in King County, WA:: The Kame project
Cognitive decline and Japanese culture in a cohort of older Japanese Americans in King County, WA:: The Kame project
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DOI：
10.1093/geronb/54b.3.s154
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发表时间：
1999-05-01
影响因子：
6.2
通讯作者：
Larson, EB
中科院分区：
文献类型：
--
作者：
Graves, AB;Rajaram, L;Larson, EB
Objectives. The prevalence of Alzheimer's disease in studies of Japanese show generally lower rates when compared with those of Caucasians. We hypothesized that among a cohort of Japanese Americans lifestyle differences would act to modify progression of the Alzheimer pathologic process over many years, resulting in a slower cognitive decline among persons whose lifestyle is more characteristically Japanese.Methods. One thousand, eight hundred and thirty-six nondemented persons were screened with the Cognitive Abilities Screening Instrument (CASI) at baseline, and 1,604 were rescreened 2 years later. Baseline questions included migration status, exposure to Japanese culture in early life and maintenance of such culture in adulthood, and other risk factors. Cognitive de dine was defined as a 2-year loss of greater than or equal to 5.15 points/100 on CASI.Results. In multivariable logistic regression, variables relating to reading, writing, and speaking Japanese, being horn or having lived in Japan in early life, and having friends who are only/mostly Japanese were inversely associated with cognitive decline (odds ratios ranged between 0.28 and 0.64, with p
