Two New Anxiolytic Phenanthrenes Found in the Medullae of Juncus effusus
Two New Anxiolytic Phenanthrenes Found in the Medullae of Juncus effusus
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DOI：
10.1177/1934578x1400900830
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发表时间：
2014-08
影响因子：
1.8
通讯作者：
Yang Wang;Guiyun Li;Qian Fu;Tai-Sen Hao;Jian-mei Huang;Hailong Zhai
中科院分区：
文献类型：
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作者：
Yang Wang;Guiyun Li;Qian Fu;Tai-Sen Hao;Jian-mei Huang;Hailong Zhai
从灯心草（Juncus effusus L.）的髓质中分离得到6个菲类化合物：2-甲氧基-7-羟基-1-甲基-5-乙烯基菲（1），灯心草素（juncusin）（2），脱氢effusol（3），灯心草素（juncusol）（4），effusol（5）和脱氢effusal（6）。化合物1和2被鉴定为新结构，两者分别在10和2.5 mg/kg剂量下表现出抗焦虑活性。
Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L. Compounds 1 and 2 were identified as being new structures, and both of them showed anxiolytic activity at dosages of 10 and 2.5 mg/kg, respectively.