Burden of liver diseases in the world
Burden of liver diseases in the world
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DOI：
10.1016/j.jhep.2018.09.014
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发表时间：
2019-01-01
影响因子：
25.7
通讯作者：
Kamath, Patrick S.
中科院分区：
文献类型：
--
作者：
Asrani, Sumeet K.;Devarbhavi, Harshad;Kamath, Patrick S.
全世界每年约有200万人死于肝病，其中100万人死于肝硬化并发症，100万人死于病毒性肝炎和肝细胞癌。肝硬化目前是全球第11大最常见死亡原因，肝癌是第16大主要死亡原因；这些疾病加起来占全球死亡人数的3.5%。肝硬化是导致残疾调整生命年数和生命损失年数的前20大原因之一，分别占全球负担的1.6%和2.1%。全世界约有20亿人饮酒，超过7500万人被诊断患有酒精使用障碍，并面临酒精相关肝病的风险。大约20亿成年人肥胖或超重，超过4亿人患有糖尿病；这两者都是非酒精性脂肪性肝病和肝细胞癌的危险因素。病毒性肝炎的全球流行率仍然很高，而药物性肝损伤作为急性肝炎的主要原因继续增加。肝移植是第二大最常见的实体器官移植，但按照目前的速度，只有不到10%的全球移植需求得到满足。尽管这些数字发人深省，但它们强调了改善公共卫生的重要机会，因为大多数肝病的病因都是可以预防的。(C) 2018年欧洲肝脏研究协会。Elsevier B.V.版权所有。
Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due to complications of cirrhosis and 1 million due to viral hepatitis and hepatocellular carcinoma. Cirrhosis is currently the 11th most common cause of death globally and liver cancer is the 16th leading cause of death; combined, they account for 3.5% of all deaths worldwide. Cirrhosis is within the top 20 causes of disability-adjusted life years and years of life lost, accounting for 1.6% and 2.1% of the worldwide burden. About 2 billion people consume alcohol worldwide and upwards of 75 million are diagnosed with alcohol-use disorders and are at risk of alcohol-associated liver disease. Approximately 2 billion adults are obese or overweight and over 400 million have diabetes; both of which are risk factors for nonalcoholic fatty liver disease and hepatocellular carcinoma. The global prevalence of viral hepatitis remains high, while drug-induced liver injury continues to increase as a major cause of acute hepatitis. Liver transplantation is the second most common solid organ transplantation, yet less than 10% of global transplantation needs are met at current rates. Though these numbers are sobering, they highlight an important opportunity to improve public health given that most causes of liver diseases are preventable. (C) 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.