The emergence of the infection of subgroup J avian leucosis virus escalated the tumour incidence in commercial Yellow chickens in Southern China in recent years
The emergence of the infection of subgroup J avian leucosis virus escalated the tumour incidence in commercial Yellow chickens in Southern China in recent years
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DOI：
10.1111/tbed.13023
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发表时间：
2019-01-01
影响因子：
4.3
通讯作者：
Wei, Ping
中科院分区：
文献类型：
--
作者：
Li, Haijuan;Wang, Peikun;Wei, Ping
2010年至2017年，共有81例疑似肿瘤的临床病例提交给我们的实验室，这些病例来自中国南方的黄鸡养殖场。在细胞培养中仔细检查肿瘤样组织样本中常见的致癌禽流感病毒，并使用聚合酶链反应（PCR）进一步分析。2010-2012年，马立克病病毒（Marek’s disease virus， MDV）单一感染是肿瘤发病的主要原因（52.4%,11/21），其次是MDV+ alv合并感染（19.1%,4/21）。从2013年开始，单一感染的禽白血病病毒J亚群（ALV-J）成为肿瘤病例的主要病原体（83.3%,5/6）。最近4年（2014-2017年），ALV- j与MDV共感染或ALV亚群间共感染发生率分别上升了23.4%和18.5%，但各共感染发生率仍略低于ALV- j单感染发生率（33.3%）。与2013年之前主要的MDV单感染病例相反，最近出现的ALV-J单感染和ALV-J共感染是导致中国南方商业地方黄鸡中发生禽病毒诱导肿瘤的主要原因。这些结果表明，所有养鸡场，特别是黄鸡养殖场应加强对ALV的根除措施，以扭转这一趋势。
A total of 81 clinical cases of suspected tumours were submitted to our laboratory from Yellow chicken farms in southern China during the years 2010 through 2017. The tumour-like tissue samples were closely examined for common oncogenic avian viruses in cell culture and further analysed using polymerase chain reaction (PCR). During 2010-2012, Marek's disease virus (MDV) mono-infection was found to be the dominant cause of the tumour incidences (52.4%, 11/21) followed by co-infection of MDV+ALVs (19.1%, 4/21). Starting from the year 2013 the mono-infection of avian leucosis virus subgroup J (ALV-J) became the dominant agent of the tumour cases (83.3%, 5/6). During the most recent four years (2014-2017), co-infections involving ALV-J and MDV or between ALV subgroups have increased (23.4% and 18.5%, respectively), but each of the co-infections was still slightly lower than the ALV-J mono-infection incidence (33.3%). In contrast to the dominant MDV mono-infection cases before 2013, more recently, the emerging ALV-J mono-infection and ALV-J co-infections were largely responsible for the occurrence of avian virus-induced tumour incidences in the commercial local Yellow breeds of chickens in southern China. These results indicate that eradication measures against ALV on all chicken farms, especially on farms with the Yellow chickens, ought to be enhanced to reverse this trend.