Zika virus productively infects primary human placenta-specific macrophages
Zika virus productively infects primary human placenta-specific macrophages
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DOI：
10.1172/jci.insight.88461
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发表时间：
2016-08-18
期刊：
影响因子：
8
通讯作者：
Fikrig, Erol
中科院分区：
文献类型：
--
作者：
Jurado, Kellie Ann;Simoni, Michael K.;Fikrig, Erol
寨卡病毒感染与先天性缺陷之间的密切联系引发了黄病毒如何能够穿过胎盘屏障到达胎儿大脑的问题。在这里，我们证明了允许寨卡病毒感染原代人胎盘巨噬细胞（通常称为霍夫鲍尔细胞）和胎盘绒毛成纤维细胞。我们还利用足月胎盘绒毛外植体证明了霍夫鲍尔细胞在离体组织中的寨卡病毒感染。除了在通常无法进入的区域内扩增感染性病毒外，霍夫鲍尔细胞的推测迁移活动可能有助于寨卡病毒向胎儿大脑传播。了解胎盘特异性细胞类型的易感性将有助于未来围绕和了解寨卡病毒相关妊娠并发症的工作。
The strong association of Zika virus infection with congenital defects has led to questions of how a flavivirus is capable of crossing the placental barrier to reach the fetal brain. Here, we demonstrate permissive Zika virus infection of primary human placental macrophages, commonly referred to as Hofbauer cells, and placental villous fibroblasts. We also demonstrate Zika virus infection of Hofbauer cells within the context of the tissue ex vivo using term placental villous explants. In addition to amplifying infectious virus within a usually inaccessible area, the putative migratory activities of Hofbauer cells may aid in dissemination of Zika virus to the fetal brain. Understanding the susceptibility of placenta-specific cell types will aid future work around and understanding of Zika virus-associated pregnancy complications.