RANTES may be predictive of later recurrent wheezing after respiratory syncytial virus bronchiolitis in infants
RANTES may be predictive of later recurrent wheezing after respiratory syncytial virus bronchiolitis in infants
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DOI：
10.1016/s1081-1206(10)62383-6
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发表时间：
2002-05-01
影响因子：
5.9
通讯作者：
Kim, SG
中科院分区：
文献类型：
--
作者：
Chung, HL;Kim, SG
背景资料：体外研究表明，RANTES强烈诱导呼吸道合胞病毒（RSV）感染的培养上气道上皮细胞。RANTES是已知的化学引诱剂和激活剂嗜酸性粒细胞。目的：我们进行这项研究，以探讨是否RANTES增加在气道自然获得RSV毛细支气管炎。RANTES水平，然后评估有关的疾病的严重程度和后来的发展反复喘息。方法：我们测量RANTES在鼻腔分泌物中的30例急性RSV毛细支气管炎。测定嗜酸性粒细胞阳离子蛋白（ECP）以评价嗜酸性粒细胞的活化。病情严重程度由初始PaO2值和喘息持续时间决定。在1年的随访中，重新评估所有婴儿是否出现后续喘息，我们研究了RANTES水平是否可以预测复发性喘息的后期发展。结果：RSV细支气管炎中的RANTES和ECP均显着高于对照组。RANTES和ECP水平之间存在显著相关性。RANTES在重度症状患者中并不显著高于轻度症状患者。RANTES在婴儿谁经历了随后的喘息显着高于婴儿who had noth.Conclusions：我们的研究结果表明，RANTES增加鼻分泌物在急性RSV毛细支气管炎，并建议，高水平的RANTES可能是预测以后的发展反复喘息。
Background: In vitro studies have shown that RANTES is strongly induced by respiratory syncytial virus (RSV) infection in cultures of upper airway epithelial cells. RANTES is known as a chemoattractant and activator for eosinophils.Objectives: We performed this study to investigate whether RANTES is increased in the airway during naturally acquired RSV bronchiolitis. RANTES levels were then evaluated in relation to the severity of illness and later development of recurrent wheezing.Methods: We measured RANTES in nasal secretions of 30 patients with acute RSV bronchiolitis. Eosinophil cationic protein (ECP) was determined to evaluate the activation of eosinophils. The severity of illness was determined by the initial PaO2 values and the duration of wheezing. At a 1-year followup, all infants were re-evaluated if they had experienced subsequent wheezing, and we investigated if RANTES levels could predict the later development of recurrent wheezing.Results: Both RANTES and ECP in RSV bronchiolitis were significantly higher than in controls. There was a significant correlation between the levels of RANTES and ECP. RANTES was not significantly higher in patients with severe symptoms than in patients with mild symptoms. RANTES in infants who had experienced subsequent wheezing was significantly higher than in infants who had not.Conclusions: Our results showed that RANTES is increased in nasal secretion during acute RSV bronchiolitis and suggest that high levels of RANTES may be predictive of later development of recurrent wheezing.