Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination
Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination
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DOI：
10.1117/1.2764460
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发表时间：
2007-07-01
影响因子：
3.5
通讯作者：
de Boer, Johannes F.
中科院分区：
文献类型：
--
作者：
Mujat, Mircea;Park, B. Hyle;de Boer, Johannes F.
光谱域光学相干层析成像(SD-OCT)和光学频域成像(OFDI)中每个光谱元素的准确波长分配是构建生物组织断层图像的前提。这对于这些技术的功能扩展变得更加关键，特别是在偏振敏感光学相干层析成像(PS-OCT)中，其中两个正交偏振通道之间的错误波长分配会导致偏振伪影。我们提出了一种波长分配的自动校准方法，该方法不需要单独的校准测量，并且可以直接应用于实际数据。在相对波长分配具有皮度计精度的PS-OCT系统中，消除了双折射伪影，导致了0.25°/100微米的残余相位误差。我们还首次展示了活体人视网膜神经纤维层的定量双折射图。(C)2007年，光学仪器工程师学会。
Accurate wavelength assignment of each spectral element for spectral-domain optical coherence tomography (SD-OCT) and optical frequency domain imaging (OFDI) is required for proper construction of biological tissue cross-sectional images. This becomes more critical for functional extensions of these techniques, especially in polarization-sensitive optical coherence tomography (PS-OCT), where incorrect wavelength assignment between the two orthogonal polarization channels leads to polarization artifacts. We present an autocalibration method for wavelength assignment that does not require separate calibration measurements and that can be applied directly on actual data. Removal of the birefringence artifact is demonstrated in a PS-OCT system with picometer accuracy in the relative wavelength assignment, resulting in a residual phase error of 0.25 deg/ 100 mu m. We also demonstrate, for the first time, a quantitative birefringence map of an in vivo human retinal nerve fiber layer. (C) 2007 Society of Photo-Optical Instrumentation Engineers.