Genome-wide association approaches for identifying loci for human height genes
Genome-wide association approaches for identifying loci for human height genes
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DOI：
10.1016/j.beem.2010.10.013
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发表时间：
2011-02-01
影响因子：
7.4
通讯作者：
Perola, Markus
中科院分区：
文献类型：
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作者：
Perola, Markus
与大多数其他人类人体测量特征一样，人类身高是一个非常可遗传的特征。迄今为止，全基因组关联研究已经确定了大约200个与身高相关的基因，这些基因具有全基因组意义。需要非常大的荟萃分析来实现这一目标。这200个身高基因参与了各种生物学上合理的生长途径，但只能解释身高变异的10%。因此，很明显，与大多数GWA研究一样，巨人联盟高度荟萃分析留下了遗传变异的主要部分无法解释。需要利用几种不同的策略和非常大的研究队列进行大量工作，以确定更多的生长基因。(C)2010爱思唯尔有限公司保留所有权利。
Human height is a very heritable trait as most of other human anthropometric traits. Genome-wide association studies have thus far identified about 200 genes associated with height with a genome-wide significance. Very large meta-analyses were needed to achieve this. These 200 height genes are involved in various biologically plausible pathways for growth, but yet explain only 10% of the variance in height. So it is obvious, that the GIANT-consortium height meta-analysis leaves, as most of GWA studies, a major part of the genetic variation unexplained. Much work utilizing several different strategies and very large study cohorts are needed to identify more genes for growth. (C) 2010 Elsevier Ltd. All rights reserved.