Repeatability, and Intra-Observer and Interobserver Agreement of Two Dimensional Perfusion Angiography in Patients with Chronic Limb Threatening Ischaemia
Repeatability, and Intra-Observer and Interobserver Agreement of Two Dimensional Perfusion Angiography in Patients with Chronic Limb Threatening Ischaemia
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DOI：
10.1016/j.ejvs.2021.02.014
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发表时间：
2021-06-14
影响因子：
5.7
通讯作者：
van den Heuvel, Daniel A. F.
中科院分区：
文献类型：
--
作者：
Ipema, Jetty;Heinen, Stefan G. H.;van den Heuvel, Daniel A. F.
Objective.二维（2D）灌注血管造影是一种从标准数字减影血管造影采集中提供定量足部灌注信息的方法。本研究的目的是测试这种方法的可靠性，在慢性肢体缺血威胁（CLTI）患者通过调查的可重复性，和观察者和interobserver agreement.Methods：20例CLTI和膝下血管内血运重建被列入一项前瞻性临床研究。治疗前，在不进行干预的情况下，以5分钟间隔采集两次灌注血管造影运行。在这些记录中，选择感兴趣的区域，并确定时间密度曲线和灌注参数。为了研究观察者内的一致性，一名观察者对每名患者的相同采集进行了五次测量。为了研究观察者之间的一致性，三名观察者对每位患者的相同采集进行测量，结果以Bland-Altman图表示，并作为每个参数的组内相关系数。结果：两名患者因主要运动伪影而被排除在重复性分析之外。对剩余18名患者的重复性分析显示，每个参数均具有良好的相关性（> .96）。所有20例患者的所有参数的观察者内和观察者间一致性极佳（1.00）。结论：CLTI患者的2D灌注血管造影的重复性和观察者内和观察者间一致性极佳。因此，当根据本研究中描述的标准化方法使用时，它是一种可靠的工具。
Objective. Two dimensional (2D) perfusion angiography is a method that provides quantitative foot perfusion information from standard digital subtraction angiography acquisitions. The aim of this study was to test the reliability of this method in patients with chronic limb threatening ischaemia (CLTI) by investigating repeatability, and intra-observer and interobserver agreement.Methods: Twenty patients with CLTI and a below the knee endovascular revascularisation were included in a prospective clinical study. Prior to treatment two perfusion angiography runs were acquired with a five minute interval without performing an intervention. In these recordings, regions of interest were selected and time density curves and perfusion parameters were determined. To investigate intra-observer agreement one observer performed five measurements on the same acquisition for each patient. To investigate interobserver agreement three observers performed measurements on the same acquisition for each patient.Results were presented in Bland-Altman plots and as the intraclass correlation coefficient per parameter. Results: Two patients were excluded from repeatability analyses because of major motion artefacts. Repeatability analyses of the 18 remaining patients showed excellent correlation for every parameter (> .96). Intra-observer and interobserver agreement for all 20 patients were excellent for all parameters (1.00).Conclusion: Repeatability and intra-observer and interobserver agreement of 2D perfusion angiography in patients with CLTI were found to be excellent. It is therefore a reliable tool when used according to the standardised methods described in this study.