Therapeutic Effect of ME1036 on Endocarditis Experimentally Induced by Methicillin-Resistant Staphylococcus aureus
Therapeutic Effect of ME1036 on Endocarditis Experimentally Induced by Methicillin-Resistant Staphylococcus aureus
复制标题
ME1036对耐甲氧西林金黄色葡萄球菌实验性心内膜炎的治疗作用
DOI：
--
复制
发表时间：
2005
影响因子：
4.9
通讯作者：
M. Yonezawa
中科院分区：
文献类型：
--
作者：
J. Nagura;K. Kijima;Mizuyo Kurazono;Sho Takahata;T. Sugano;Yukari Tanaka;Y. Hirai;Keiko Yamada;Y. Takayama;E. Shitara;M. Yonezawa
摘要采用兔耐甲氧西林金黄色葡萄球菌（MRSA）心内膜炎模型，比较了新型肠外碳青霉烯类抗生素ME 1036与万古霉素的疗效。与万古霉素相比，ME 1036在较低剂量或较短时间内用于治疗MRSA心内膜炎时，可降低赘生物中的细菌计数。
ABSTRACT The efficacy of ME1036, a novel parenteral carbapenem, was compared with that of vancomycin by using a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA) endocarditis. Compared with vancomycin, ME1036 reduced the bacterial counts in the vegetations at a lower dosage or over a shorter period of administration when it was used for the treatment of MRSA endocarditis.