"The Loss of Golden Touch": Mitochondria-Organelle Interactions, Metabolism, and Cancer.
"The Loss of Golden Touch": Mitochondria-Organelle Interactions, Metabolism, and Cancer.
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作者：
Audano M;Pedretti S;Ligorio S;Crestani M;Caruso D;De Fabiani E;Mitro N
线粒体代表细胞的能量中心，它们的功能受到它们与其他亚细胞器的束缚的持续影响。线粒体与内质网、溶酶体、细胞骨架、过氧化物酶体和细胞核以多种方式相互作用，包括信号转导、囊泡运输和膜接触位点，以调节能量代谢、生物合成过程、凋亡和细胞更新。肿瘤发生通常与线粒体功能障碍有关，这可能是与不同细胞器或结构相互作用改变的结果。本综述的目的是提供一个更新的概述细胞器间的通信和相互作用和癌细胞的代谢之间的联系，重点是线粒体。最近发表的关于这些方面的若干评论证明了对这一领域的极大兴趣。在这里，我们的目标是（1）总结最近的证据，支持在肿瘤中观察到的代谢重新布线和适应深刻影响细胞器动力学和细胞功能，反之亦然;（2）讨论潜在机制的见解，如果可用的话;（3）批判性地提出需要填补的领域空白，全面了解肿瘤细胞的生物学。还概述了与上述方面相关的癌细胞的耐药性和可药物性弱点。
Mitochondria represent the energy hub of cells and their function is under the constant influence of their tethering with other subcellular organelles. Mitochondria interact with the endoplasmic reticulum, lysosomes, cytoskeleton, peroxisomes, and nucleus in several ways, ranging from signal transduction, vesicle transport, and membrane contact sites, to regulate energy metabolism, biosynthetic processes, apoptosis, and cell turnover. Tumorigenesis is often associated with mitochondrial dysfunction, which could likely be the result of an altered interaction with different cell organelles or structures. The purpose of the present review is to provide an updated overview of the links between inter-organellar communications and interactions and metabolism in cancer cells, with a focus on mitochondria. The very recent publication of several reviews on these aspects testifies the great interest in the area. Here, we aim at (1) summarizing recent evidence supporting that the metabolic rewiring and adaptation observed in tumors deeply affect organelle dynamics and cellular functions and vice versa; (2) discussing insights on the underlying mechanisms, when available; and (3) critically presenting the gaps in the field that need to be filled, for a comprehensive understanding of tumor cells’ biology. Chemo-resistance and druggable vulnerabilities of cancer cells related to the aspects mentioned above is also outlined.
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影响因子：
64.5
作者：
Cárdenas C;Miller RA;Smith I;Bui T;Molgó J;Müller M;Vais H;Cheung KH;Yang J;Parker I;Thompson CB;Birnbaum MJ;Hallows KR;Foskett JK
通讯作者：
Foskett JK
影响因子：
11.4
作者：
Csordás, G;Thomas, AP;Hajnóczky, G
通讯作者：
Hajnóczky, G
影响因子：
11.2
作者：
Boggs AE;Vitolo MI;Whipple RA;Charpentier MS;Goloubeva OG;Ioffe OB;Tuttle KC;Slovic J;Lu Y;Mills GB;Martin SS
通讯作者：
Martin SS
影响因子：
4.6
作者：
Ando, Koji;Yokochi, Tomoki;Nakagawara, Akira
通讯作者：
Nakagawara, Akira
影响因子：
7.7
作者：
Ciscato, Francesco;Filadi, Riccardo;Rasola, Andrea
通讯作者：
Rasola, Andrea