Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors
Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors
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DOI：
10.1016/j.febslet.2006.08.013
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发表时间：
2006-09-18
期刊：
影响因子：
3.5
通讯作者：
Mutoh, T.
中科院分区：
文献类型：
--
作者：
Mihara, T.;Ueda, A.;Mutoh, T.
我们筛选了各种神经系统疾病患者的血清中存在的抗中性鞘糖脂抗体，只发现他们在血清中复发性多囊炎与边缘脑炎patients.Neutral鞘糖脂驻留在膜脂筏，高亲和力的神经生长因子（NGF）受体，Trk是共定位。因此，我们研究了这些抗体是否影响NGF在NGF反应细胞中的作用。结果强烈表明，这些抗体增强神经生长因子诱导的Trk自身磷酸化和神经突生长以及神经丝M的表达。这些数据有力地表明，这些抗中性鞘糖脂抗体对NGF-Trk介导的细胞内信号转导途径具有功能性影响。(c)2006年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
We screened sera from patients with various neurological disorders for the presence of anti-neutral glycosphingolipids antibodies and only found them in sera from relapsing polychondritis with limbic encephalitis patients.Neutral glycosphingolipids are resident in membrane lipid rafts where high affinity nerve growth factor (NGF) receptor, Trk is co-localized. Therefore, we examined whether these antibodies influence the action of NGF in NGF-responsive cells. The results strongly suggest that these antibodies enhance NGF-induced Trk autophosphorylation and neurite outgrowth as well as neurofilament M expression. These data strongly indicate that these anti-neutral glycosphingolipids antibodies have an functional impact on NGF-Trk-mediated intracellular signal transduction pathway. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.