Increased EEG sigma and beta power during NREM sleep in primary insomnia
Increased EEG sigma and beta power during NREM sleep in primary insomnia
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DOI：
10.1016/j.biopsycho.2012.08.009
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发表时间：
2012-12-01
影响因子：
2.6
通讯作者：
Nissen, Christoph
中科院分区：
文献类型：
--
作者：
Spiegelhalder, Kai;Regen, Wolfram;Nissen, Christoph
原发性失眠的高觉醒模型表明，睡眠过程中缺乏减弱的觉醒可能会导致非恢复性睡眠。在目前的研究中，我们检测了25名原发性失眠症患者和29名睡眠良好者对照的标准频段的脑电频谱功率值，作为睡眠期间皮质唤醒和睡眠保护机制的指标。在NREM阶段2睡眠期间，原发性失眠症患者的脑电β频段和西格玛频段的频谱功率值显著升高。在其他频段和快速眼动睡眠期间，均未观察到差异。基于先前的研究表明，脑电β活动是皮质觉醒的标志，而脑电睡眠纺锤体(Sigma)活动是睡眠保护机制的指标，我们的发现可能为以下概念提供进一步的证据：促进觉醒和保护睡眠的神经活动模式的同时激活有助于原发性失眠患者的非恢复性睡眠体验。(C)2012爱思唯尔B.V.保留所有权利。
The hyperarousal model of primary insomnia suggests that a deficit of attenuating arousal during sleep might cause the experience of non-restorative sleep. In the current study, we examined EEG spectral power values for standard frequency bands as indices of cortical arousal and sleep protecting mechanisms during sleep in 25 patients with primary insomnia and 29 good sleeper controls. Patients with primary insomnia demonstrated significantly elevated spectral power values in the EEG beta and sigma frequency band during NREM stage 2 sleep. No differences were observed in other frequency bands or during REM sleep. Based on prior studies suggesting that EEG beta activity represents a marker of cortical arousal and EEG sleep spindle (sigma) activity is an index of sleep protective mechanisms, our findings may provide further evidence for the concept that a simultaneous activation of wake-promoting and sleep-protecting neural activity patterns contributes to the experience of non-restorative sleep in primary insomnia. (C) 2012 Elsevier B.V. All rights reserved.