TYPE-SPECIFIC OPSONIC ANTIBODIES IN STREPTOCOCCAL PYODERMA
TYPE-SPECIFIC OPSONIC ANTIBODIES IN STREPTOCOCCAL PYODERMA
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DOI：
10.1128/iai.10.6.1356-1361.1974
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发表时间：
1974-01-01
影响因子：
3.1
通讯作者：
NELSON, KE
中科院分区：
文献类型：
--
作者：
BISNO, AL;NELSON, KE
对密西西比州霍姆斯县 Headstart 中心的黑人儿童进行了链球菌脓皮病的前瞻性研究。10 月初从其中 28 名儿童身上采集的血清，在过去 3 个月内一次或多次检测了针对从他们身上分离出的两种流行的 A 组链球菌皮肤菌株之一的调理性抗体。这两种链球菌菌株（A 和 B）属于以前未被识别的 M 型。 10 名受试者 (36%) 具有可通过间接杀菌试验检测到的同源血清型抗体：这包括 10 名感染 B 株的受试者中的 6 名，但 18 名感染 A 株的受试者中只有 4 名（P < 0.05）。在 17 名仅从皮肤损伤中分离出 A 型或 B 型菌株的儿童中，12% 的儿童产生了针对感染血清型的类型特异性抗体 (TSA)。相比之下，11 名受试者从咽喉培养物中分离出这些菌株（无论是否伴有脓皮病），72% 的受试者可检测到 TSA（P < 0.01）。针对链球菌胞外产物或非类型特异性细胞抗原的抗体的产生与 TSA 的产生之间没有明显的关系。这些结果表明，脓皮链球菌感染后确实会发生类型特异性免疫反应。此类抗体产生的频率是可变的，并且似乎与许多因素有关，包括感染菌株的免疫学特性和细菌定植的位点。咽部携带可能代表了对 A 族链球菌皮肤菌株获得性免疫发展的重要机制。
Prospective studies of streptococcal pyoderma were carried out among black children enrolled in Project Headstart centers in Holmes County, Miss. Sera collected from 28 of these children in early October were tested for opsonic antibodies to one of two prevalent skin strains of group A streptococci isolated from them on one or more occasions over the preceding 3 months. The two streptococcal strains (A and B) belong to M-types previously unrecognized. Ten subjects (36%) had antibody to their homologous serotypes detectable by the indirect bactericidal test: this included 6 of 10 subjects infected with strain B but only 4 of 18 infected with strain A (P< 0.05). Of 17 children who had strains A or B isolated from skin lesions only, 12% developed type-specific antibodies (TSA) against the infecting serotype. In contrast, 11 subjects had these strains isolated from throat cultures (either with or without associated pyoderma), and 72% had detectable TSA (P< 0.01). There was no demonstrable relationship between the development of antibodies to streptococcal extracellular products or to non-type-specific cellular antigens and the development of TSA. These results demonstrate that type-specific immune responses do occur following infection with pyoderma streptococci. The frequency with which such antibodies develop is variable and appears related to a number of factors, including the immunologic properties of the infecting strain and the site of bacterial colonization. Pharyngeal carriage may represent an important mechanism for development of acquired immunity to skin strains of group A streptococci.