SUPPRESSION OF URATE CRYSTAL-INDUCED CANINE JOINT INFLAMMATION BY HETEROLOGOUS ANTI-POLYMORPHONUCLEAR LEUKOCYTE SERUM
SUPPRESSION OF URATE CRYSTAL-INDUCED CANINE JOINT INFLAMMATION BY HETEROLOGOUS ANTI-POLYMORPHONUCLEAR LEUKOCYTE SERUM
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DOI：
10.1002/art.1780110204
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发表时间：
1968-01-01
影响因子：
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通讯作者：
GRALLA, EJ
中科院分区：
文献类型：
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作者：
CHANG, YH;GRALLA, EJ
在狗中，通过注射兔抗狗中性粒细胞血清来消耗中性粒细胞抑制晶体诱导的后膝关节炎症。炎症反应恢复正常，白细胞减少症恢复。这些观察结果类似于长春碱诱导的白细胞减少犬的实验。中性粒细胞在尿酸盐结晶引起的犬关节炎中起重要作用。
In the dog, depletion of PMN by the injection of rabbit anti-dog-PMN serum suppressed crystal-induced stifle joint inflammation. The inflammatory response returned to normal with recovery from leukopenia. These observations resemble experiments with vinblastine-induced leukopenic dogs. PMN play an essential role in the urate crystal-induced inflammation in the canine joint.