An early modern human from Romania with a recent Neanderthal ancestor.
An early modern human from Romania with a recent Neanderthal ancestor.
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DOI：
10.1038/nature14558
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发表时间：
2015-08-13
期刊：
影响因子：
64.8
通讯作者：
Pääbo S
中科院分区：
文献类型：
--
作者：
Fu Q;Hajdinjak M;Moldovan OT;Constantin S;Mallick S;Skoglund P;Patterson N;Rohland N;Lazaridis I;Nickel B;Viola B;Prüfer K;Meyer M;Kelso J;Reich D;Pääbo S
尼安德特人被认为在39，000 - 41，000年前在欧洲消失，但他们贡献了欧亚大陆现今人类DNA的1%到3%。在这里，我们分析了来自罗马尼亚Petertera cu Oase的37，000 - 42，000岁现代人的DNA。虽然该标本含有少量的人类DNA，但我们使用富集策略来分离出能够提供有关其与尼安德特人和现代人类关系的信息的位点。我们发现，欧斯人的基因组中有6%到9%来自尼安德特人，比迄今为止测序的任何其他现代人都多。尼安德特人祖先的三个染色体片段大小超过50厘摩，表明这个人最近有一个尼安德特人的祖先，直到四到六代。然而，欧斯人与后来的欧洲人的等位基因并不比与东亚人的等位基因多，这表明欧斯人对后来的欧洲人没有实质性的贡献。
Neanderthals are thought to have disappeared in Europe ~39,000–41,000 years ago but they have contributed one to three percent of the DNA of present-day people in Eurasia. Here, we analyze DNA from a 37,000–42,000-year-old modern human from Peştera cu Oase, Romania. Although the specimen contains small amounts of human DNA, we use an enrichment strategy to isolate sites that are informative about its relationship to Neanderthals and present-day humans. We find that on the order of six to nine percent of the genome of the Oase individual is derived from Neanderthals, more than any other modern human sequenced to date. Three chromosomal segments of Neanderthal ancestry are over 50 centimorgans in size, indicating that this individual had a Neanderthal ancestor as recently as four to six generations back. However, the Oase individual does not share more alleles with later Europeans than with East Asians, suggesting that the Oase population did not contribute substantially to later humans in Europe.