Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene.
Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene.
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仙台病毒特异性抗体和纯合小鼠 CD8 T 细胞反应的修饰，以破坏白细胞介素 4 基因。
DOI：
10.1128/jvi.71.3.2518-2521.1997
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Doherty,PC
中科院分区：
文献类型：
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作者：
Mo,XY;Sangster,MY;Tripp,RA;Doherty,PC
白细胞介素-4（IL-4）基因的纯合性破坏（-/-）并没有明显改变高度敏感的129/J小鼠品系中仙台病毒感染的严重程度。病毒从呼吸道中清除，支气管肺泡灌洗回收的细胞群中存在强效细胞毒性T淋巴细胞（CTL）效应子。然而，在感染后第7天，病毒特异性CTL前体（p）在IL-4 -/-小鼠的脾脏和局部淋巴结中的流行率一致地降低。此外，病毒特异性血清免疫球蛋白G1（IgG 1）水平大大降低，在淋巴组织中检测到很少的IgG 1产生细胞。对IgG 1类别转换的影响是预期的，但以前未观察到病毒特异性免疫应答的CTLp数量减少。
Homozygous disruption (-/-) of the interleukin-4 (IL-4) gene did not obviously modify the severity of Sendai virus infection in the highly susceptible 129/J mouse strain. The virus was cleared from the respiratory tract, and potent cytotoxic T lymphocyte (CTL) effectors were present in the cell population recovered by bronchoalveolar lavage. However, the prevalence of virus-specific CTL precursors (p) was consistently diminished in the spleen and regional lymph nodes of the IL-4 -/- mice at day 7 after infection. Also, virus-specific serum immunoglobulin G1 (IgG1) levels were greatly reduced and few IgG1-producing cells were detected in the lymphoid tissue. The effect on IgG1 class switching was to be expected, but the decrease in CTLp numbers has not been observed previously for a virus-specific immune response.