18F-FDG PET imaging for identifying the dynamics of intestinal disease caused by SFTSV infection in a mouse model.
18F-FDG PET imaging for identifying the dynamics of intestinal disease caused by SFTSV infection in a mouse model.
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DOI：
10.18632/oncotarget.6645
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发表时间：
2016-01-05
期刊：
影响因子：
--
通讯作者：
Morita K
中科院分区：
文献类型：
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作者：
Hayasaka D;Nishi K;Fuchigami T;Shiogama K;Onouchi T;Shimada S;Tsutsumi Y;Morita K
严重发热伴血小板减少综合征(SFTS)是一种新出现的疾病，可导致发热、肠炎、血小板减少和白细胞减少，在高达30%的病例中可能是致命的。然而，严重疾病的发病机制尚不完全清楚。分子成像方法，如正电子发射断层扫描(PET)，是提供疾病进展的实时动力学、药代动力学评估和疾病进展诊断的功能性活体成像技术。分子成像也可能为探索病毒感染的发病机制提供有用的方法。因此，本研究的目的是通过PET成像对体内SFTSV感染的病理特征进行成像。在小鼠模型中，我们显示18F-FDG的累积清楚地将肠道部位识别为病变部位。我们还证明了18F-FDG PET成像可以评估同一个体内的疾病进展和对抗血清治疗的反应。这是第一份展示SFTSV感染的分子成像策略的报告。我们的结果为临床前研究提供了潜在的有用信息，如阐明SFTSV体内感染的机制和评估治疗SFTS的药物。
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease that causes fever, enteritis, thrombocytopenia, and leucopenia and can be fatal in up to 30% of cases. However, the mechanism of severe disease is not fully understood. Molecular imaging approaches, such as positron-emission tomography (PET), are functional in vivo imaging techniques that provide real-time dynamics of disease progression, assessments of pharmacokinetics, and diagnoses for disease progression. Molecular imaging also potentially provides useful approaches to explore the pathogenesis of viral infections. Thus, the purpose of this study was to image the pathological features of SFTSV infection in vivo by PET imaging. In a mouse model, we showed that 18F-FDG accumulations clearly identified the intestinal tract site as a pathological site. We also demonstrated that 18F-FDG PET imaging can assess disease progression and response to antiserum therapy within the same individual. This is the first report demonstrating a molecular imaging strategy for SFTSV infection. Our results provide potentially useful information for preclinical studies such as the elucidation of the mechanism of SFTSV infection in vivo and the assessment of drugs for SFTS treatment.